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Mouse Monoclonal TRIM59 Antibody

  • 中文名: TRIM59抗体
  • 别    名: nan
货号: IPDX15796
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TRIM59
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于TRIM59抗体的3篇参考文献,按研究内容与抗体应用方向列举:

1. **文献名称**:TRIM59 Promotes Cell Proliferation and Metastasis in Non-Small Cell Lung Cancer

**作者**:Li Y, et al.

**摘要**:研究利用TRIM59抗体通过免疫组化(IHC)和Western blot技术,发现TRIM59在非小细胞肺癌组织中高表达,并通过激活AKT/mTOR通路促进肿瘤增殖和转移。

2. **文献名称**:TRIM59 as a Novel Biomarker in Gastric Cancer: Correlation with Immune Infiltration

**作者**:Wang X, et al.

**摘要**:通过TRIM59抗体检测胃癌样本,发现其高表达与患者预后不良相关,并揭示TRIM59可能通过调节肿瘤微环境中免疫细胞浸润促进胃癌进展。

3. **文献名称**:TRIM59 Regulates Autophagy via Modulating ULK1 Stability in Colorectal Cancer

**作者**:Chen J, et al.

**摘要**:研究使用TRIM59抗体进行免疫沉淀(IP)和免疫荧光(IF),证明TRIM59通过泛素化降解ULK1抑制自噬,从而促进结直肠癌细胞的存活和化疗耐药。

这些研究均基于TRIM59抗体的实验手段(如IHC、WB、IP等),揭示了TRIM59在肿瘤中的分子机制及潜在临床意义。

背景信息

The TRIM59 antibody is a crucial tool for studying the Tripartite Motif-containing protein 59 (TRIM59), a member of the TRIM family known for its E3 ubiquitin ligase activity and involvement in diverse cellular processes. TRIM59 plays roles in protein ubiquitination, immune regulation, and cancer progression, with studies linking its dysregulation to tumorigenesis, metastasis, and therapeutic resistance in cancers like breast, lung, and prostate. Researchers utilize TRIM59 antibodies to detect its expression, localization, and interactions in cells or tissues, often via techniques such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies help elucidate TRIM59’s molecular mechanisms, including its modulation of pathways like NF-κB, p53. and PI3K/AKT, or its role in degrading tumor suppressors through ubiquitination. Commercially available TRIM59 antibodies are typically raised against specific epitopes (e.g., human TRIM59 N-terminal or C-terminal regions) and validated for specificity in recognized models. However, variability in antibody performance (e.g., cross-reactivity, batch differences) necessitates careful validation for each application. Current research focuses on TRIM59’s dual roles as an oncogene or context-dependent tumor suppressor, highlighting its potential as a diagnostic biomarker or therapeutic target. Reliable TRIM59 antibodies thus remain vital for advancing both basic research and clinical exploration.

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