Mouse Monoclonal TRIM59 Antibody

The TRIM59 antibody is a crucial tool for studying the Tripartite Motif-containing protein 59 (TRIM59), a member of the TRIM family known for its E3 ubiquitin ligase activity and involvement in diverse cellular processes. TRIM59 plays roles in protein ubiquitination, immune regulation, and cancer progression, with studies linking its dysregulation to tumorigenesis, metastasis, and therapeutic resistance in cancers like breast, lung, and prostate. Researchers utilize TRIM59 antibodies to detect its expression, localization, and interactions in cells or tissues, often via techniques such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies help elucidate TRIM59’s molecular mechanisms, including its modulation of pathways like NF-κB, p53. and PI3K/AKT, or its role in degrading tumor suppressors through ubiquitination. Commercially available TRIM59 antibodies are typically raised against specific epitopes (e.g., human TRIM59 N-terminal or C-terminal regions) and validated for specificity in recognized models. However, variability in antibody performance (e.g., cross-reactivity, batch differences) necessitates careful validation for each application. Current research focuses on TRIM59’s dual roles as an oncogene or context-dependent tumor suppressor, highlighting its potential as a diagnostic biomarker or therapeutic target. Reliable TRIM59 antibodies thus remain vital for advancing both basic research and clinical exploration.