| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human NPPC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NPPC(Natriuretic Peptide Precursor C)抗体的参考文献示例(注：部分文献信息为示例性概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**: *"C-type natriuretic peptide regulates endochondral bone formation through antagonism of the MEK/ERK pathway"*
**作者**: Yoshiko, Y. et al.
**摘要**: 研究探讨了NPPC在软骨细胞分化中的作用，通过使用特异性抗体阻断NPPC信号通路，发现其通过抑制MEK/ERK通路调控骨骼生长板发育，为侏儒症机制研究提供依据。
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2. **文献名称**: *"NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus expansion in mammals"*
**作者**: Zhang, M. et al.
**摘要**: 利用NPPC抗体检测卵母细胞周围颗粒细胞中NPPC的表达水平，揭示NPPC通过结合受体NPR2维持卵母细胞减数分裂停滞，为生殖生物学研究提供新靶点。
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3. **文献名称**: *"Targeting C-type natriuretic peptide signaling in pulmonary hypertension"*
**作者**: Ogawa, Y. et al.
**摘要**: 通过免疫组化及NPPC抗体标记，发现肺动脉高压模型中NPPC表达异常升高，提示其可能通过旁分泌机制参与血管重塑，为治疗策略开发提供方向。
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4. **文献名称**: *"Role of C-type natriuretic peptide in cardiac fibrosis and angiogenesis"*
**作者**: Nakao, K. et al.
**摘要**: 研究使用NPPC中和抗体阻断心肌细胞旁分泌信号，证实NPPC通过抑制TGF-β通路减轻心脏纤维化，为心力衰竭治疗提供潜在干预手段。
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**注意**：以上文献名称及内容为示例性概括，具体研究请通过PubMed、Google Scholar等平台检索关键词(如“NPPC antibody”“CNP signaling”)获取真实文献。
NPPC (Natriuretic Peptide Precursor C) antibodies are tools used to study the biological roles of C-type natriuretic peptide (CNP), a key member of the natriuretic peptide family. CNP, encoded by the NPPC gene, is a paracrine signaling molecule involved in regulating cardiovascular homeostasis, bone growth, and tissue remodeling. It binds to the NPR-B receptor, activating intracellular cGMP signaling pathways that influence cell proliferation, differentiation, and extracellular matrix synthesis. CNP is particularly critical in skeletal development, where it stimulates endochondral ossification, and in vascular tone modulation.
Antibodies targeting NPPC/CNP are widely utilized in research to localize CNP expression in tissues, quantify its levels in biological samples, or inhibit its activity to investigate downstream mechanisms. For instance, they help elucidate CNP's role in conditions like cardiovascular diseases, skeletal dysplasia, and fibrosis. Therapeutic applications are also being explored, such as using neutralizing antibodies to counteract CNP overactivity in pathologies like cancer or inflammatory disorders. However, challenges remain in ensuring antibody specificity, minimizing cross-reactivity with related peptides (e.g., ANP, BNP), and optimizing pharmacokinetics for clinical use. Ongoing studies aim to refine NPPC antibody design to enhance their research and therapeutic potential.
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