| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DSC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与DSC2(Desmocollin-2)抗体相关的文献示例(注：部分信息基于领域知识模拟，请核实原文)：
1. **"Autoantibodies against desmocollin-2 in arrhythmogenic right ventricular cardiomyopathy"**
*Authors: Smith A, et al.*
摘要：研究报道了在心律失常性右室心肌病(ARVC)患者血清中检测到抗DSC2抗体，提示其可能通过破坏心肌细胞间桥粒连接参与疾病进展。
2. **"Desmocollin-2 regulates colorectal cancer cell proliferation via EGFR signaling pathway"**
*Authors: Zhang L, et al.*
摘要：通过DSC2抗体阻断实验，发现DSC2缺失可激活EGFR通路促进结直肠癌细胞增殖，表明DSC2在肿瘤抑制中具有潜在作用。
3. **"Immunohistochemical analysis of desmosomal proteins in cutaneous squamous cell carcinoma"**
*Authors: Brown K, et al.*
摘要：使用DSC2抗体进行免疫组化分析，发现皮肤鳞状细胞癌中DSC2表达显著下调，提示其表达缺失可能与肿瘤侵袭性相关。
4. **"DSC2 antibody-based functional study reveals its role in cardiomyocyte adhesion"**
*Authors: Garcia E, et al.*
摘要：利用DSC2特异性抗体干扰心肌细胞实验，证实DSC2对细胞间机械连接和电信号传导至关重要，为心脏疾病机制提供新见解。
(注：以上文献标题及内容为模拟示例，实际文献需通过PubMed/Google Scholar检索确认)
Desmocollin-2 (DSC2), a member of the desmosomal cadherin family, is a calcium-dependent transmembrane glycoprotein critical for cell-cell adhesion in epithelial and cardiac tissues. As a core component of desmosomes, DSC2 interacts with other desmosomal proteins (e.g., desmogleins, plakoglobin) to maintain tissue integrity and mechanical stability. DSC2 antibodies are immunological tools targeting specific epitopes of the DSC2 protein, widely used in research to investigate desmosome biology, epithelial barrier function, and intercellular signaling pathways.
Clinically, DSC2 mutations are linked to arrhythmogenic right ventricular cardiomyopathy (ARVC), a heart disorder characterized by fibrofatty myocardial replacement. DSC2 antibodies aid in diagnosing such genetic disorders by detecting protein expression anomalies in tissue samples. In oncology, altered DSC2 expression is observed in cancers like squamous cell carcinoma, where its downregulation may correlate with tumor progression and metastasis. Researchers utilize DSC2 antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to study these pathological mechanisms.
Recent studies also explore DSC2's role in inflammatory skin diseases and autoimmune disorders. Commercial DSC2 antibodies are typically developed in rabbits or mice, validated for specificity across human and model organisms. Ongoing research aims to clarify DSC2's dual roles in tissue homeostasis and disease, potentially identifying therapeutic targets for cardiac or epithelial pathologies.
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