| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human COLEC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于COLEC12抗体的3篇模拟参考文献示例(基于现有研究领域推测，非真实文献)：
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1. **文献名称**: *"Characterization of COLEC12 Expression in Macrophage Polarization Using a Novel Monoclonal Antibody"*
**作者**: Holmskov U, et al.
**摘要**: 本研究开发了一种针对COLEC12蛋白的单克隆抗体，并验证了其在免疫组化和流式细胞术中的特异性。通过该抗体发现，COLEC12在M2型巨噬细胞中高表达，提示其在调节抗炎反应中的潜在作用。
2. **文献名称**: *"COLEC12 Antibody Blockade Attenuates Atherosclerotic Plaque Formation in Mice"*
**作者**: Smith A, et al.
**摘要**: 利用COLEC12中和抗体进行功能研究，发现抑制COLEC12可减少血管内皮炎症因子释放，显著延缓小鼠动脉粥样硬化斑块进展，表明其作为治疗靶点的潜力。
3. **文献名称**: *"COLEC12-Specific Antibody Reveals Its Role in Tumor-Associated Angiogenesis"*
**作者**: Garcia-Rico E, et al.
**摘要**: 通过免疫荧光染色和Western blot分析，使用抗COLEC12抗体证实其在肿瘤血管内皮细胞中的高表达，并发现其通过调控VEGF信号通路促进血管生成。
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**备注**：以上文献为示例性内容，实际研究中请通过PubMed、Google Scholar等平台以“COLEC12 antibody”或“collectin 12 immune detection”等关键词检索真实文献。
COLEC12 (Collectin Subfamily Member 12), also known as CL-12 or Collectin placenta 1. is a soluble C-type lectin protein belonging to the collectin family, which plays a role in innate immunity. It is characterized by a collagen-like domain and a carbohydrate-binding lectin domain, enabling it to recognize pathogen-associated molecular patterns (PAMPs) and damaged host cells. COLEC12 is primarily expressed in placental tissue and endothelial cells, where it contributes to immune surveillance by promoting opsonization, phagocytosis, and complement activation. Its interaction with ligands, such as microbial surface sugars or apoptotic cell markers, suggests involvement in microbial defense and clearance of cellular debris.
Antibodies targeting COLEC12 are critical tools for studying its biological functions and pathological roles. They enable detection of COLEC12 expression in tissues or fluids, facilitate mechanistic studies in infection, inflammation, and cancer, and help explore its potential as a diagnostic or therapeutic biomarker. For instance, COLEC12 antibodies have been used to investigate its role in preeclampsia, tumor angiogenesis, and immune modulation in the tumor microenvironment. Current research also focuses on its dual role in promoting or suppressing inflammation, depending on context, which may inform therapeutic strategies for autoimmune diseases or sepsis. These antibodies are typically validated in assays like ELISA, Western blot, and immunohistochemistry.
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