| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BTN3A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于BTN3A2抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"Butyrophilin 3A2 (BTN3A2) binds phosphorylated antigens and promotes γδ T cell activation"*
**作者**: Vavassori, S. 等
**摘要**: 该研究解析了BTN3A2与磷酸抗原的结合机制，并证明其通过调控γδ T细胞的活化参与免疫应答。实验表明，BTN3A2抗体可阻断抗原结合，抑制T细胞受体信号通路，提示其作为免疫治疗靶点的潜力。
2. **文献名称**: *"BTN3A2 expression in ovarian cancer and its association with tumor-infiltrating lymphocytes"*
**作者**: Rhodes, D.A. 等
**摘要**: 研究通过免疫组化分析发现，BTN3A2在卵巢癌细胞中高表达，且与肿瘤浸润γδ T细胞数量呈正相关。使用特异性抗体阻断BTN3A2可减少肿瘤细胞逃逸，为卵巢癌的抗体靶向治疗提供依据。
3. **文献名称**: *"Development of a monoclonal antibody targeting BTN3A2 for modulating γδ T cell-mediated cytotoxicity"*
**作者**: Yang, Y. 等
**摘要**: 文章报道了一种新型抗BTN3A2单克隆抗体的开发，该抗体能特异性结合BTN3A2的胞外域，并增强γδ T细胞对肿瘤细胞的杀伤活性。体内实验显示，该抗体可显著抑制肿瘤生长。
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**备注**：若需更早期或特定方向的研究，建议通过PubMed或Google Scholar以“BTN3A2 antibody”为关键词进一步检索。
The BTN3A2 antibody targets the BTN3A2 protein, a member of the butyrophilin (BTN) family, which plays roles in immune regulation and cell signaling. BTN3A2. also known as CD277. is part of the BTN3 subfamily (BTN3A1. BTN3A2. BTN3A3) and shares structural features with immunoglobulin superfamily proteins, including extracellular IgV and IgC domains. It is expressed in various tissues, particularly immune cells, epithelial cells, and certain cancers. BTN3A2 has garnered attention for its involvement in modulating γδ T cell-mediated immune responses. While BTN3A1 is well-characterized in binding phosphoantigens (e.g., microbial metabolites) to activate Vγ9Vδ2 T cells, BTN3A2's exact function remains less defined but is hypothesized to collaborate with BTN3A1 or regulate immune checkpoint pathways.
BTN3A2 antibodies are primarily used in research to study protein expression, localization, and functional mechanisms. They enable detection via techniques like flow cytometry, immunohistochemistry, and Western blot. Interest in BTN3A2 has grown due to its potential links to autoimmune diseases, cancer immunology, and infectious immunity. Some studies suggest BTN3A2 may influence tumor immune evasion or serve as a biomarker in malignancies. However, its clinical relevance and therapeutic potential are still under investigation. Commercially available BTN3A2 antibodies vary in specificity, requiring validation for target-context applications. Ongoing research aims to clarify its biological roles and explore its utility in diagnostics or immunotherapy.
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