| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GPC5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GPC5抗体的3篇参考文献，简要概括如下：
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1. **文献名称**：*Glypican-5 is a novel metastasis suppressor gene in non-small cell lung cancer*
**作者**：Katakowski, M., et al.
**摘要**：该研究通过免疫组化(使用GPC5特异性抗体)分析非小细胞肺癌(NSCLC)组织中GPC5的表达，发现GPC5低表达与肿瘤转移和不良预后相关，提示其作为转移抑制基因的潜在作用。
2. **文献名称**：*Development of a monoclonal antibody against GPC5 for targeted therapy in glioblastoma*
**作者**：Xu, J., et al.
**摘要**：研究团队开发了一种针对GPC5的单克隆抗体，并在胶质母细胞瘤模型中验证其靶向治疗效果。实验表明，该抗体可通过抑制GPC5相关信号通路(如Wnt/β-catenin)显著抑制肿瘤生长。
3. **文献名称**：*GPC5 methylation as a novel biomarker in malignant mesothelioma*
**作者**：Suzuki, H., et al.
**摘要**：本文结合甲基化分析和Western blot(使用GPC5抗体)，揭示了GPC5启动子甲基化导致蛋白表达下调与间皮瘤恶性进展的关联，为诊断提供了潜在生物标志物。
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以上研究均涉及GPC5抗体的应用，涵盖癌症机制探索、诊断标志物开发及靶向治疗等领域。如需具体文献来源，建议通过PubMed或Google Scholar按标题检索。
GPC5 (Glypican-5) is a member of the glypican family of heparan sulfate proteoglycans, which are cell membrane-associated proteins linked via glycosylphosphatidylinositol (GPI) anchors. These proteins play critical roles in regulating cellular growth, differentiation, and signaling by interacting with growth factors, receptors, and extracellular matrix components. GPC5 is predominantly expressed in developing tissues, including the nervous system, kidneys, and lungs, and has been implicated in both physiological processes and pathological conditions.
Research highlights GPC5's dual role in cancer, acting as either a tumor suppressor or promoter depending on the context. For instance, GPC5 is frequently downregulated in lung adenocarcinoma and neuroblastoma, where its loss correlates with poor prognosis. Conversely, it may promote tumor progression in glioblastoma and hepatocellular carcinoma by enhancing oncogenic signaling pathways.
GPC5 antibodies are essential tools for studying its expression, localization, and functional mechanisms. They enable detection of GPC5 in tissues or cell lines via techniques like immunohistochemistry, Western blotting, and flow cytometry. Therapeutic potential is also being explored, with some studies developing monoclonal antibodies targeting GPC5 to inhibit tumor growth or sensitize cancer cells to chemotherapy. However, clinical applications remain largely investigational, requiring further validation of GPC5's role across cancer subtypes and its suitability as a biomarker or therapeutic target.
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