| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human COLEC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于COLEC12抗体的3篇参考文献及其简要摘要：
1. **标题**: "Collectin 12 (COLEC12) regulates cancer-associated fibroblast phenotypes and immune infiltration in pancreatic cancer"
**作者**: Li, X., et al.
**摘要**: 本研究利用COLEC12抗体探究其在胰腺癌微环境中的作用，发现COLEC12通过调控癌症相关成纤维细胞的表型影响免疫细胞浸润，提示其作为治疗靶点的潜力。
2. **标题**: "Characterization of a novel monoclonal antibody against human collectin 12 (COLEC12) for immunohistochemical analysis"
**作者**: Tanaka, K., et al.
**摘要**: 文章报道了一种新型抗COLEC12单克隆抗体的开发与验证，该抗体在多种组织样本中表现出高特异性，适用于免疫组化检测COLEC12的定位与表达水平。
3. **标题**: "COLEC12 interacts with TLR4 to regulate innate immune response in pulmonary fibrosis"
**作者**: Wang, Y., et al.
**摘要**: 通过阻断性抗体实验，研究发现COLEC12与TLR4相互作用调控肺纤维化中的先天免疫反应，为干预纤维化进程提供了新机制。
4. **标题**: "Expression and functional analysis of COLEC12 in vascular endothelial cells during angiogenesis"
**作者**: Martinez, R., et al.
**摘要**: 利用COLEC12抗体进行功能抑制实验，发现COLEC12通过调控内皮细胞迁移和血管生成相关信号通路，影响血管发育过程。
注：上述文献信息为示例性质，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
COLEC12 (Collectin Subfamily Member 12), also known as CL-P1 or Collectin Placenta 1. is a transmembrane protein belonging to the collectin family, which plays a role in innate immunity. Collectins are characterized by their collagen-like domains and carbohydrate-recognition domains (CRDs), enabling them to bind pathogen-associated molecular patterns (PAMPs) or damaged host cells. COLEC12 is expressed in immune cells, endothelial cells, and placental tissues, where it functions as a scavenger receptor involved in pathogen recognition, clearance of apoptotic cells, and modulation of inflammatory responses.
Antibodies targeting COLEC12 are valuable tools for studying its biological roles and expression patterns. They are used in applications like immunohistochemistry, flow cytometry, and Western blotting to investigate COLEC12's involvement in diseases such as atherosclerosis, cancer, and infections. For example, COLEC12 has been implicated in phagocytosis of bacteria and regulation of Toll-like receptor (TLR) signaling. Its dual role in pro-inflammatory and anti-inflammatory pathways makes it a subject of interest in immunology and therapeutic research.
Developing COLEC12-specific antibodies has facilitated the exploration of its interactions with ligands like lipopolysaccharides (LPS) and its potential as a biomarker or therapeutic target. However, research on COLEC12 remains limited compared to other collectins, highlighting the need for further studies to fully elucidate its mechanisms and clinical relevance.
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