Mouse Monoclonal KIFBP Antibody

The KIFBP (Kinesin Family Binding Protein) antibody is a crucial tool for studying the functional roles of KIFBP, a regulatory protein that interacts with kinesin motor proteins involved in intracellular transport. Kinesins are ATP-dependent molecular motors that move along microtubules, facilitating the transport of organelles, vesicles, and macromolecules. KIFBP modulates kinesin activity by binding to specific kinesin family members, influencing their stability, localization, or cargo-binding capacity. For example, KIFBP is known to interact with KIF1 family proteins, which are critical for axonal transport in neurons. Dysregulation of KIFBP has been implicated in neurological disorders, such as Charcot-Marie-Tooth disease, and cancer, where aberrant intracellular transport contributes to tumor progression. The KIFBP antibody enables researchers to detect and quantify KIFBP expression in cells or tissues via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It also aids in exploring KIFBP’s interactions with kinesins and its role in cellular processes like mitosis, organelle trafficking, and signal transduction. Studies using this antibody have provided insights into how KIFBP mutations or altered expression impact cellular homeostasis, offering potential therapeutic targets for related diseases.