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Mouse Monoclonal KIFBP Antibody

  • 中文名: KIFBP抗体
  • 别    名: nan
货号: IPDX15670
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenPurified recombinant fragment of human KIFBP
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于KIFBP抗体的3篇参考文献示例(注:由于KIFBP相关文献较少,以下内容基于类似研究方向的文献结构概括,实际文献需通过学术数据库查询):

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1. **文献名称**:*KIFBP regulates axonal transport of synaptic vesicles through interaction with KIF1A*

**作者**:Smith A, et al.

**摘要**:本研究揭示了KIFBP(Kinesin家族结合蛋白)通过与驱动蛋白KIF1A的直接相互作用,调控神经元轴突运输的分子机制。利用特异性KIFBP抗体进行免疫共沉淀和免疫荧光实验,发现KIFBP缺失会导致突触小泡运输障碍,提示其在神经退行性疾病中的潜在作用。

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2. **文献名称**:*Dysregulation of KIFBP in colorectal cancer and its association with patient prognosis*

**作者**:Chen L, et al.

**摘要**:通过免疫组化实验(使用KIFBP特异性抗体),研究发现结直肠癌组织中KIFBP表达显著上调,且与肿瘤转移和患者不良预后相关。机制研究表明KIFBP通过调控细胞周期蛋白影响癌细胞增殖。

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3. **文献名称**:*A novel KIFBP antibody reveals its role in mitochondrial distribution*

**作者**:Wang Y, et al.

**摘要**:本研究开发了一种高特异性KIFBP单克隆抗体,验证其在Western blot和免疫细胞化学中的应用。实验发现KIFBP参与线粒体在细胞内的定位调控,敲低KIFBP会导致线粒体分布紊乱,影响细胞能量代谢。

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**备注**:KIFBP研究相对小众,以上为模拟文献框架。建议通过PubMed或Google Scholar以“KIFBP antibody”“KIFBP function”为关键词检索最新文献。如需具体文章,可提供疾病或分子机制方向进一步筛选。

背景信息

The KIFBP (Kinesin Family Binding Protein) antibody is a crucial tool in studying the role of KIFBP, a protein implicated in regulating kinesin motor proteins involved in intracellular transport. Kinesins are microtubule-dependent motors that facilitate the movement of organelles, vesicles, and macromolecules within cells. KIFBP interacts with specific kinesin family members, modulating their activity, stability, or localization, thereby influencing processes like mitotic spindle formation, axonal transport, and cell division. Dysregulation of KIFBP has been linked to pathologies, including neurodegenerative disorders and cancers, where altered intracellular transport contributes to disease progression. Researchers employ KIFBP antibodies in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular distribution, and interactions in cellular or tissue samples. These studies help elucidate KIFBP's mechanistic contributions to both normal physiology and disease states. Recent work also explores its potential as a therapeutic target or biomarker. The antibody's specificity and sensitivity are critical for ensuring accurate experimental results, driving advances in understanding kinesin-related cellular dynamics and associated disorders.

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