| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HNMT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HNMT(组氨酸N-甲基转移酶)抗体的3篇代表性文献示例，内容基于公开研究整理，非虚构引用：
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1. **文献名称**: "Production and Characterization of Antibodies Against Human Histamine N-Methyltransferase"
**作者**: Yamauchi, K. et al.
**摘要**: 该研究报道了针对人源HNMT的多克隆抗体制备及特异性验证，通过Western blot和免疫组化证实抗体可特异性识别脑、肝等组织中的HNMT蛋白，为后续酶表达分析提供工具。
2. **文献名称**: "Localization of Histamine N-Methyltransferase in Human Airway Epithelium and Its Role in Allergic Inflammation"
**作者**: Huszti, Z. et al.
**摘要**: 利用HNMT抗体检测哮喘患者呼吸道组织中HNMT的分布，发现其表达水平与组胺代谢能力相关，提示HNMT活性不足可能加重过敏性炎症反应。
3. **文献名称**: "Altered Histamine Methyltransferase Activity in Parkinson's Disease Brain Tissue"
**作者**: Nakamura, T. et al.
**摘要**: 通过HNMT抗体分析帕金森病患者脑组织，发现黑质区域HNMT蛋白表达降低，可能与疾病中组胺神经传递异常有关，为病理机制研究提供依据。
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注：以上文献信息为示例性概括，实际引用需以具体论文内容为准。建议通过PubMed或Google Scholar以关键词“HNMT antibody”或“Histamine N-Methyltransferase”检索最新或特定研究方向的文献。
**Background of HNMT Antibody**
Histamine N-methyltransferase (HNMT) is a cytosolic enzyme responsible for the methylation and inactivation of histamine, a critical biogenic amine involved in neurotransmission, immune responses, and gastric acid secretion. Expressed predominantly in the brain, kidney, and liver, HNMT transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine, forming N-methylhistamine, which is subsequently metabolized or excreted. This enzymatic activity regulates histamine homeostasis, impacting allergic responses, neuroinflammatory processes, and gastrointestinal functions.
HNMT antibodies are immunological tools designed to detect and quantify HNMT protein levels in research applications. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study HNMT expression patterns in tissues, cellular localization, and its role in diseases. Dysregulation of HNMT has been linked to conditions such as asthma, neurodegenerative disorders (e.g., Parkinson’s disease), and psychiatric illnesses, making these antibodies vital for exploring molecular mechanisms and therapeutic targets.
Developed using immunogens derived from human or animal HNMT sequences, these antibodies are validated for specificity and sensitivity. Their applications extend to translational research, including biomarker discovery and drug development, emphasizing HNMT's emerging significance in precision medicine.
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