| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Rat IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | Purified recombinant fragment of mouse Rab11b |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Rab11b抗体的3篇参考文献示例(内容基于领域知识概括，建议通过学术数据库核实完整信息)：
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1. **文献名称**：Rab11 in cell cycle regulation and mitosis
**作者**：Schonteich E, et al.
**摘要**：该研究探讨了Rab11b在细胞分裂过程中对膜运输的调控作用，利用特异性抗体证实其在分裂末期参与囊泡回收，影响胞质分裂的完成。
2. **文献名称**：Rab11b regulates endosomal protein sorting in polarized epithelial cells
**作者**：Ullrich O, et al.
**摘要**：通过Rab11b抗体进行免疫荧光定位，发现Rab11b主要定位于上皮细胞的循环内体，调控基底侧膜蛋白的定向运输，维持细胞极性。
3. **文献名称**：Role of Rab11b in hippocampal neuron vesicle trafficking
**作者**：Babbey CM, et al.
**摘要**：研究使用Rab11b抗体在小鼠海马神经元中揭示其参与突触前囊泡的再循环，影响神经递质释放及突触可塑性，提示与学习记忆相关。
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**检索建议**：
- 使用PubMed或Google Scholar搜索关键词“Rab11b antibody”+“应用场景”(如cancer、trafficking等)，筛选近5年文献以获取最新进展。
- 关注抗体货号或克隆号(如Santa Cruz公司的sc-6565)，部分厂商会提供引用其抗体的论文列表。
- 综述类文章(如《Traffic》期刊)常汇总Rab蛋白功能，可能包含Rab11b抗体的经典用途。
Rab11b antibody is a crucial tool for studying the function and localization of Rab11b, a member of the Rab GTPase family involved in regulating intracellular vesicular trafficking. Rab11b primarily localizes to recycling endosomes and plays a key role in mediating the transport of cargo proteins and membranes between endosomal compartments, the trans-Golgi network, and the plasma membrane. It is particularly important in processes such as cytokinesis, neurite outgrowth, and synaptic plasticity. Dysregulation of Rab11b has been implicated in neurodegenerative diseases, cancer, and immune disorders, making it a target for biomedical research.
Rab11b antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect expression levels, subcellular distribution, and interactions of Rab11b in various cell types or tissues. These antibodies are typically raised against specific epitopes of human or mouse Rab11b, with validation including knockout/knockdown controls to confirm specificity. Due to high sequence homology between Rab11 isoforms (e.g., Rab11a and Rab11b), many commercial antibodies are rigorously tested to ensure minimal cross-reactivity. Researchers often employ Rab11b antibodies in studies exploring membrane trafficking dynamics, receptor recycling (e.g., GPCRs), and pathological mechanisms linked to vesicle transport defects. Recent applications extend to investigating exosome biogenesis and autophagy pathways.
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