| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于TRIM10抗体的参考文献及其摘要概括(注：文献为示例，非真实存在)：
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1. **文献名称**：*TRIM10 regulates erythroid differentiation via modulation of GATA1 activity*
**作者**：Smith A, et al.
**摘要**：该研究利用TRIM10特异性抗体，通过免疫沉淀和Western blot技术，揭示了TRIM10在红系分化中通过与转录因子GATA1相互作用调控造血干细胞分化的分子机制。
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2. **文献名称**：*The role of TRIM10 in innate immune response to viral infections*
**作者**：Lee JH, et al.
**摘要**：本文通过免疫荧光染色(使用TRIM10抗体)和基因敲除实验，证明TRIM10通过促进RIG-I信号通路激活，增强细胞对RNA病毒(如流感病毒)的干扰素应答。
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3. **文献名称**：*TRIM10 antibody-based biomarker discovery in leukemia*
**作者**：Zhang Y, et al.
**摘要**：研究开发了一种高特异性TRIM10单克隆抗体，并用于白血病患者样本的免疫组化分析，发现TRIM10在急性髓系白血病(AML)中高表达，提示其作为潜在治疗靶点的价值。
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**注**：若需真实文献，建议在PubMed或Google Scholar中检索关键词“TRIM10 antibody”或“TRIM10 function”，并筛选近年发表的实验研究。
The TRIM10 antibody is a research tool designed to detect and study the TRIpartite Motif-containing protein 10 (TRIM10), a member of the TRIM family of proteins. TRIM proteins are characterized by a conserved N-terminal domain structure, typically comprising a RING finger, one or two B-box domains, and a coiled-coil region, which mediate diverse cellular processes such as ubiquitination, immune response, and transcriptional regulation. TRIM10. also known as hematopoietic RING finger 1 (HERF1), is predominantly expressed in erythroid cells and plays a role in erythroid differentiation and proliferation. Studies suggest its involvement in regulating cell cycle progression and apoptosis during red blood cell development, with potential implications in hematological disorders like thalassemia.
TRIM10 antibodies are widely used in applications like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions. Research has explored its role in modulating the ubiquitin-proteasome system and its interplay with transcription factors such as GATA-1. critical for erythropoiesis. Dysregulation of TRIM10 has been linked to abnormal hematopoiesis and malignancies, prompting interest in its oncogenic or tumor-suppressive functions. Additionally, TRIM10's involvement in innate immunity and response to viral infections highlights its broader biological significance. The antibody serves as a key reagent in elucidating TRIM10's molecular mechanisms and therapeutic potential in blood-related diseases and cancer.
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