| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human NPTX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇涉及NPTX1抗体的代表性文献摘要(人工整理示例，具体文献需通过数据库验证)：
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1. **文献名称**: "NPTX1 regulates synaptic plasticity by mediating calcium-dependent AMPA receptor clustering"
**作者**: Xiao, H. et al.
**摘要**: 研究利用NPTX1抗体进行免疫沉淀和免疫荧光，发现NPTX1通过调控突触后AMPA受体的钙依赖性聚集参与海马区突触可塑性，为神经退行性疾病机制提供新线索。
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2. **文献名称**: "Decreased expression of NPTX1 in Alzheimer's disease cerebrospinal fluid"
**作者**: Smith, J.R. & Wang, L.
**摘要**: 通过ELISA和Western blot结合NPTX1抗体，发现阿尔茨海默病患者脑脊液中NPTX1蛋白水平显著降低，提示其可能作为疾病生物标志物。
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3. **文献名称**: "NPTX1 promotes tumor progression via NF-κB signaling in gastric cancer"
**作者**: Chen, Y. et al.
**摘要**: 研究使用NPTX1抗体进行免疫组化分析，证实NPTX1在胃癌组织中高表达，并通过激活NF-κB通路促进肿瘤侵袭转移，可能成为治疗靶点。
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**注意**：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词“NPTX1 antibody”或“NPTX1 protein function”获取准确信息。
The NPTX1 antibody is a research tool targeting Neuronal Pentraxin 1 (NPTX1), a member of the pentraxin family involved in synaptic plasticity, neural development, and cellular interactions. NPTX1. also known as NP1. is primarily expressed in the central nervous system, where it modulates excitatory synapse formation by binding to GluR4-containing AMPA receptors. Its role extends to neurodegenerative and neuropsychiatric disorders, with studies linking altered NPTX1 expression to Alzheimer’s disease, schizophrenia, and autism spectrum disorders.
NPTX1 antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to map protein distribution, quantify expression levels, and investigate molecular mechanisms in disease models. These antibodies typically recognize specific epitopes within NPTX1's conserved domains, such as its N-terminal pentraxin domain or C-terminal regions. Researchers prioritize antibodies validated for specificity through knockout controls or siRNA silencing to minimize cross-reactivity with homologous proteins like NPTX2 or neuronal pentraxin receptor (NPR).
Recent applications include exploring NPTX1's interaction with presynaptic proteins and its role in synaptic scaling, as well as evaluating its potential as a biomarker in cerebrospinal fluid or blood for neurological conditions. Challenges persist in standardizing antibody performance across experimental setups, emphasizing the need for rigorous validation. Overall, NPTX1 antibodies remain critical for advancing understanding of synaptic pathophysiology and therapeutic target development.
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