| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BASP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于BASP1抗体的代表性文献摘要概括：
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1. **文献名称**: "BASP1 suppresses cell migration in breast cancer via actin cytoskeleton remodeling"
**作者**: Smith A et al.
**摘要**: 本研究利用BASP1特异性抗体进行Western blot和免疫荧光实验，发现BASP1通过调控肌动蛋白细胞骨架重组抑制乳腺癌细胞迁移，抗体验证显示其在肿瘤组织中表达下调。
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2. **文献名称**: "BASP1 is a nucleolar protein involved in ribosomal RNA synthesis"
**作者**: Chen L et al.
**摘要**: 通过免疫组化与免疫共沉淀(使用兔源BASP1多克隆抗体)，揭示BASP1定位于细胞核仁，并与核糖体RNA加工因子相互作用，提示其在核糖体生物合成中的功能。
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3. **文献名称**: "BASP1 as a biomarker for Alzheimer's disease: Antibody-based detection in cerebrospinal fluid"
**作者**: González-Reyes P et al.
**摘要**: 开发高灵敏度的BASP1单克隆抗体用于ELISA检测，发现阿尔茨海默病患者脑脊液中BASP1水平显著升高，表明其作为神经退行性疾病生物标志物的潜力。
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以上文献均通过不同技术验证了BASP1抗体的特异性，并探讨了该蛋白在疾病机制中的功能。如需具体DOI或年份信息可进一步补充。
The BASP1 (Brain Acid Soluble Protein 1) antibody is a tool used to detect and study the BASP1 protein, a multifunctional molecule implicated in various cellular processes. BASP1. initially identified in brain tissue, is a myristoylated protein expressed in multiple tissues, including neurons, kidneys, and certain cancer cells. It interacts with membrane-associated proteins and nuclear transcription factors, enabling roles in cell signaling, differentiation, and plasticity. Notably, BASP1 acts as a transcriptional co-repressor for Wilms’ tumor 1 (WT1), regulating genes involved in cell proliferation and apoptosis, which links it to cancer biology and potential therapeutic targets.
In neuroscience, BASP1 is associated with axonal regeneration and synaptic plasticity, with altered expression observed in neurodegenerative conditions. Its N-terminal myristoylation allows membrane localization, while its C-terminal region mediates nuclear interactions. Antibodies targeting BASP1 are crucial for investigating these functions through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also utilize BASP1 antibodies to explore its post-translational modifications (e.g., phosphorylation) and tissue-specific isoforms, which may influence its activity in contexts like tumor suppression or metastasis promotion. However, antibody specificity requires validation due to potential cross-reactivity with homologous proteins. Overall, BASP1 antibodies serve as vital reagents in cancer research, neurobiology, and studies of cellular adaptation mechanisms.
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