| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TACO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TACO1抗体的3篇参考文献，包括文献名称、作者及摘要内容概括：
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1. **文献名称**: *"TACO1 Gene Mutations Cause a Mitochondrial Translation Defect Associated with a Late-Onset Mitochondrial Disorder"*
**作者**: Weraarpachai, W. et al.
**摘要**: 本研究揭示了TACO1基因突变导致线粒体翻译缺陷的机制，并开发了特异性TACO1抗体用于患者细胞中蛋白表达的检测。通过Western blot和免疫荧光实验，发现突变患者的TACO1蛋白水平显著降低，证实了其在维持线粒体呼吸链功能中的关键作用。
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2. **文献名称**: *"Characterization of TACO1 as a Mitochondrial Protein Involved in COX Assembly"*
**作者**: Antonicka, H. et al.
**摘要**: 该研究利用定制TACO1抗体探究了其在细胞色素C氧化酶(COX)组装中的功能。实验表明，TACO1与线粒体核糖体相互作用，其缺失会导致COX活性下降。抗体验证显示TACO1在多种组织中的差异性表达，支持其组织特异性调控假说。
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3. **文献名称**: *"Antibody-Based Profiling of Mitochondrial Dysregulation in Neurological Disorders"*
**作者**: Richter, U. et al.
**摘要**: 研究通过高通量抗体筛选平台分析了TACO1等线粒体蛋白在神经退行性疾病中的表达变化。TACO1抗体被用于检测患者脑组织样本，结果显示其表达水平与疾病严重程度呈负相关，提示其作为潜在生物标志物的价值。
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**备注**：若需获取具体文献全文或更多细节，建议通过PubMed或Google Scholar输入标题或作者进一步检索。部分研究可能以TACO1的功能分析为主，抗体开发或应用可能隐含在方法学部分。
The TACO1 (Translational Activator of Cytochrome c Oxidase 1) antibody is a tool used to study the TACO1 protein, which plays a critical role in mitochondrial function. TACO1 is a nuclear-encoded mitochondrial protein essential for the synthesis of cytochrome c oxidase (COX), a key enzyme in the electron transport chain. Specifically, TACO1 acts as a translational activator, ensuring the proper expression of mitochondrial DNA-encoded COX subunit I (MT-CO1), a core component of COX complex assembly. Mutations in the TACO1 gene are linked to mitochondrial encephalopathies, such as Leigh syndrome, characterized by severe neurological deficits and COX deficiency.
The TACO1 antibody enables researchers to detect and quantify TACO1 protein levels in tissues or cultured cells, aiding in the investigation of mitochondrial disorders and energy metabolism dysregulation. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study TACO1 expression patterns, subcellular localization, and interactions. Additionally, this antibody supports research into cellular responses to oxidative stress, aging, and diseases involving mitochondrial dysfunction, such as neurodegenerative diseases and cancer. By elucidating TACO1's regulatory mechanisms, the antibody contributes to understanding how mitochondrial translation defects underlie pathological conditions, potentially guiding therapeutic strategies targeting mitochondrial protein synthesis. Commercial TACO1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity.
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