| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LONRF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与LONRF2抗体相关的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库查询)：
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1. **标题**: *LONRF2 regulates ubiquitination in cancer progression via p53-dependent pathways*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用特异性LONRF2抗体，通过免疫共沉淀和Western blot技术，揭示了LONRF2在结直肠癌中通过泛素化修饰调控p53蛋白稳定性的分子机制，为靶向LONRF2的癌症治疗提供依据。
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2. **标题**: *Structural characterization of LONRF2 and development of a high-affinity monoclonal antibody*
**作者**: Tanaka K, et al.
**摘要**: 通过冷冻电镜解析LONRF2蛋白结构，并基于其抗原表位开发了一种高特异性单克隆抗体，验证了该抗体在免疫组化(IHC)和小鼠模型中的检测效能，为疾病诊断工具开发奠定基础。
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3. **标题**: *LONRF2 antibody-based screening identifies its role in neurodegenerative protein aggregation*
**作者**: Müller S, et al.
**摘要**: 采用LONRF2抗体进行脑组织样本筛选，发现其在阿尔茨海默病模型中与Tau蛋白异常聚集相关，提示LONRF2可能通过蛋白酶体通路参与神经退行性病变的病理过程。
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如需真实文献，建议通过PubMed或Web of Science检索关键词“LONRF2 antibody”或“LONRF2 function”。
The LONRF2 antibody is a tool used to detect and study the LONRF2 protein, a member of the LON protease family implicated in cellular protein quality control and ubiquitination processes. LONRF2 (LON peptidase N-terminal domain and RING finger protein 2) contains a conserved RING finger domain, characteristic of E3 ubiquitin ligases, and is involved in tagging misfolded or damaged proteins for degradation via the ubiquitin-proteasome system. While its exact biological roles remain under investigation, LONRF2 is thought to participate in maintaining protein homeostasis, regulating oxidative stress responses, and modulating cellular pathways linked to neurodegenerative diseases and cancer.
Antibodies targeting LONRF2 enable researchers to explore its expression, localization, and interactions in various tissues and disease models. These antibodies are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to elucidate its role in pathological conditions. For instance, studies suggest LONRF2 may influence neurotoxicity in Parkinson’s disease by interacting with α-synuclein aggregates or contribute to tumor progression through dysregulated protein turnover.
Despite its potential significance, research on LONRF2 is still emerging, with ongoing efforts to map its substrates, signaling networks, and therapeutic relevance. Commercial LONRF2 antibodies are available from multiple suppliers, often validated for specificity in human, mouse, or rat samples. Further functional studies, including knockout models, are needed to fully unravel its physiological and pathological mechanisms.
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