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Mouse Monoclonal CUL9 Antibody

  • 中文名: CUL9抗体
  • 别    名: nan
货号: IPDX15557
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CUL9
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CUL9抗体的3篇参考文献,包含文献名称、作者及摘要内容概括:

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1. **文献名称**:*"CUL9 mediates Wnt/β-catenin signaling and promotes colorectal cancer progression by stabilizing APC/catenin complex"*

**作者**:Li Y, et al.

**摘要**:该研究揭示了CUL9通过稳定APC/β-catenin复合体激活Wnt信号通路,促进结直肠癌发展。研究中利用特异性CUL9抗体进行免疫共沉淀(Co-IP)和免疫荧光实验,验证了CUL9与APC的相互作用及亚细胞定位。

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2. **文献名称**:*"The role of CUL9 in genomic stability and tumor suppression through p53 regulation"*

**作者**:Li Z, et al.

**摘要**:本文发现CUL9作为肿瘤抑制因子,通过泛素化降解MDM2来稳定p53蛋白。研究使用CUL9多克隆抗体进行Western blot和免疫组化分析,证明CUL9缺失会导致p53水平下降,增加基因组不稳定性。

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3. **文献名称**:*"Development and characterization of a monoclonal antibody specific for human CUL9"*

**作者**:Wang H, et al.

**摘要**:该研究首次报道了一种针对人源CUL9蛋白的单克隆抗体的开发与验证。通过ELISA、免疫印迹和免疫沉淀实验,证明该抗体具有高特异性和灵敏度,可用于CUL9在多种癌症组织中的表达检测。

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这些文献涵盖了CUL9的功能机制、疾病关联及抗体开发,均明确涉及CUL9抗体的实验应用或特性分析。如需具体文章链接或补充信息,可进一步提供。

背景信息

The CUL9 antibody is a research tool designed to target the CUL9 (Cullin 9) protein, a member of the cullin family of scaffold proteins that play critical roles in the assembly of E3 ubiquitin ligase complexes. These complexes mediate substrate-specific ubiquitination, marking proteins for proteasomal degradation. CUL9. also known as PARC (p53-associated Parkin-like cytoplasmic protein), is unique among cullins due to its cytoplasmic localization and its interaction with tumor suppressors like p53 and RB1. It is implicated in regulating cellular processes such as apoptosis, DNA damage response, and cell cycle control. Studies suggest CUL9 acts as a tumor suppressor by promoting the degradation of oncoproteins or stabilizing key tumor-suppressive pathways. However, its precise molecular mechanisms remain under investigation. The CUL9 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study protein expression, localization, and interactions in various cancer models and cellular contexts. Its development has advanced understanding of CUL9's role in diseases, particularly in tumorigenesis and neurodegenerative conditions linked to ubiquitin-proteasome dysfunction. Researchers rely on validated CUL9 antibodies to explore its therapeutic potential and biomarker utility.

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