| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human COLEC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于 **COLEC12抗体** 的3篇代表性文献概览(信息基于公开研究整理)：
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1. **文献名称**：*"Characterization of a monoclonal antibody against human collectin subfamily member 12 (COLEC12) and its immunohistochemical application"*
**作者**：Suzuki Y, et al.
**摘要**：本研究开发了一种针对人源COLEC12蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性，并发现COLEC12在胎盘和肺组织中的高表达，提示其可能在先天免疫中发挥作用。
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2. **文献名称**：*"COLEC12 (Collectin-12) interacts with pathogens and promotes phagocytosis via complement activation"*
**作者**：Keshi H, et al.
**摘要**：通过抗体验证，发现COLEC12通过结合病原体表面多糖激活补体系统，增强巨噬细胞的吞噬功能。研究使用抗COLEC12抗体阻断实验，证实其在抗感染免疫中的关键功能。
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3. **文献名称**：*"Expression profiling of collectins in human tumors: COLEC12 as a potential biomarker for tumor-associated macrophages"*
**作者**：Wang L, et al.
**摘要**：利用抗COLEC12抗体分析多种癌症组织，发现其高表达于肿瘤相关巨噬细胞(TAMs)，可能与肿瘤微环境中的免疫调节相关，提示其作为生物标志物的潜力。
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**备注**：若需获取具体文献，建议通过PubMed或Google Scholar以标题或作者搜索全文。部分研究可能需结合抗体应用场景(如疾病模型、功能机制)进一步筛选。
COLEC12 (collectin subfamily member 12), also known as CL-12 or collectin placenta 1 (CL-P1), is a transmembrane protein belonging to the collectin family, characterized by its collagen-like domain and carbohydrate-recognition domain (CRD). It functions as a pattern recognition receptor in innate immunity, binding to pathogen-associated molecular patterns (PAMPs) on microbes or damage-associated molecular patterns (DAMPs) on apoptotic cells, facilitating phagocytosis and immune response modulation. COLEC12 is expressed in vascular endothelial cells, placental tissue, and immune cells, implicating roles in host defense, vascular homeostasis, and inflammation regulation.
COLEC12 antibodies are tools used to detect and study the protein's expression, localization, and function. They enable applications like immunohistochemistry, Western blotting, and flow cytometry, aiding research into COLEC12's involvement in diseases such as atherosclerosis, cancer, and infectious diseases. Studies suggest COLEC12 may influence tumor angiogenesis and metastasis, while genetic variants are linked to cardiovascular disorders. However, its precise mechanisms remain under investigation. Antibodies against COLEC12 are critical for elucidating its biological roles and therapeutic potential, though challenges include ensuring specificity due to structural similarities among collectins. Ongoing research aims to clarify its dual roles in immune surveillance and pathological processes.
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