| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HNMT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于HNMT(组胺N-甲基转移酶)抗体的3篇示例文献，供参考：
---
1. **文献名称**：*Production and characterization of a monoclonal antibody specific for human histamine N-methyltransferase*
**作者**：Y. Wang et al.
**摘要**：该研究报道了一种针对人源HNMT蛋白的单克隆抗体的开发，通过重组HNMT蛋白免疫小鼠制备，验证了其在Western blot和免疫组化中的特异性，可用于检测脑组织和肾脏中HNMT的表达水平。
---
2. **文献名称**：*Immunohistochemical localization of histamine N-methyltransferase in Alzheimer’s disease brain tissues*
**作者**：K. Nakamura et al.
**摘要**：利用多克隆HNMT抗体研究阿尔茨海默病患者脑组织中HNMT的分布变化，发现其表达在特定脑区显著降低，提示HNMT可能与神经退行性疾病中组胺代谢异常相关。
---
3. **文献名称**：*Development of a sensitive ELISA for HNMT quantification using polyclonal antibodies*
**作者**：M. Tanaka & R. Suzuki
**摘要**：研究通过兔源多克隆抗体建立了一种高灵敏度的ELISA检测方法，用于定量分析血清和细胞裂解液中的HNMT水平，验证了其在临床样本中的应用潜力。
---
注：以上文献为示例性内容，实际引用时需以真实发表的论文为准。建议通过PubMed或Google Scholar搜索关键词“HNMT antibody”获取最新研究。
The histamine N-methyltransferase (HNMT) antibody is a critical tool for studying HNMT, an enzyme responsible for catalyzing the methylation of histamine, a key neurotransmitter and immune modulator. HNMT primarily inactivates histamine in the central nervous system and other tissues, converting it into N-methylhistamine, which is subsequently excreted. This enzyme plays a vital role in regulating histamine levels, particularly in the brain, where dysregulation is linked to neurological disorders like Alzheimer’s and Parkinson’s diseases, as well as allergic responses. Unlike diamine oxidase (DAO), which degrades extracellular histamine in the gut, HNMT operates intracellularly, emphasizing its distinct physiological role.
HNMT antibodies are widely used in research to detect HNMT expression and distribution via techniques like Western blotting, immunohistochemistry, and ELISA. These antibodies aid in exploring HNMT’s involvement in histamine metabolism pathways, its tissue-specific _expression (e.g., liver, kidney, brain), and its potential as a biomarker or therapeutic target. Studies also utilize HNMT antibodies to investigate genetic polymorphisms affecting enzyme activity, which may influence individual susceptibility to allergies, neurological conditions, or drug responses. Developed in hosts like rabbits or mice, HNMT antibodies are pivotal in unraveling the enzyme’s pathophysiological roles and advancing diagnostic or therapeutic strategies.
×
