| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LRRN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是模拟生成的关于LRRN1抗体的参考文献示例(仅供参考，实际文献需通过学术数据库查询)：
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1. **"LRRN1 regulates neuronal migration and cortical layer formation during brain development"**
*Authors: Smith A, et al.*
**摘要**: 本研究利用特异性LRRN1抗体进行免疫组化分析，发现LRRN1在小鼠胚胎大脑皮层神经元中高表达，并参与神经元迁移和皮质层结构的形成。抗体验证通过Western blot和敲除模型确认特异性。
2. **"LRRN1 as a novel biomarker in colorectal cancer: Immunohistochemical analysis using a monoclonal antibody"**
*Authors: Zhang L, et al.*
**摘要**: 通过开发高亲和力LRRN1单克隆抗体，研究团队在结直肠癌组织中检测到LRRN1蛋白的异常高表达，提示其可能作为肿瘤进展的潜在生物标志物。抗体特异性通过siRNA敲降实验验证。
3. **"LRRN1 interacts with the Wnt/β-catenin signaling pathway in stem cell maintenance"**
*Authors: Lee J, et al.*
**摘要**: 本研究使用LRRN1抗体进行共免疫沉淀和Western blot实验，揭示LRRN1通过调控Wnt/β-catenin通路维持干细胞多能性。抗体在多种细胞系中显示出良好的物种交叉反应性。
4. **"Characterization of LRRN1 antibody for flow cytometry and its application in immune cell profiling"**
*Authors: Brown K, et al.*
**摘要**: 文章详细描述了商业化LRRN1抗体的优化实验条件(如流式细胞术)，并应用于外周血单核细胞分群分析，发现LRRN1在特定T细胞亚群中的差异性表达。
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**提示**：建议通过PubMed或Google Scholar搜索最新文献，关键词组合如“LRRN1 antibody”、“LRRN1 immunohistochemistry”或结合具体研究领域(如神经科学、癌症)。部分抗体厂商(如Abcam、CST)的产品说明书也可能引用相关文献。
**Background of LRRN1 Antibody**
LRRN1 (Leucine-Rich Repeat Neuronal Protein 1) is a member of the leucine-rich repeat (LRR) superfamily, characterized by repeating units of 20–30 amino acids rich in leucine residues. These proteins are involved in protein-protein interactions, cell signaling, and neural development. LRRN1 is predominantly expressed in the nervous system and has been implicated in neuronal differentiation, synaptic plasticity, and axon guidance. Its structure, featuring LRR domains, suggests roles in extracellular ligand binding or intracellular signal transduction.
Antibodies targeting LRRN1 are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in mapping LRRN1 distribution in brain regions or cultured neurons. Research using LRRN1 antibodies has explored its involvement in neurodevelopmental disorders, neurodegenerative diseases, and cancer. For example, altered LRRN1 expression has been linked to glioblastoma progression and cognitive deficits in mouse models.
Recent studies also highlight LRRN1’s potential role in immune regulation, expanding its relevance beyond neuroscience. Validated LRRN1 antibodies (polyclonal or monoclonal) are critical for ensuring specificity, particularly given the structural similarities among LRR family proteins. Commercial availability of these antibodies supports ongoing research into LRRN1’s molecular mechanisms and therapeutic applications.
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