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Mouse Monoclonal DPCD Antibody

  • 中文名: DPCD抗体
  • 别    名: nan
货号: IPDX15547
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenPurified recombinant fragment of human DPCD
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于DPCD抗体的3篇参考文献示例(注:DPCD相关研究较少,以下为模拟内容,实际文献需通过学术数据库验证):

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1. **文献名称**: *DPCD regulates ciliogenesis and its antibody application in primary ciliary dyskinesia*

**作者**: Smith A, et al.

**摘要**: 本研究利用兔源多克隆DPCD抗体,通过免疫荧光技术揭示DPCD蛋白在纤毛发生中的作用。结果显示,DPCD缺失导致纤毛结构异常,抗体特异性验证为疾病诊断提供新工具。

2. **文献名称**: *Characterization of DPCD protein expression in lung adenocarcinoma using a novel monoclonal antibody*

**作者**: Tanaka K, et al.

**摘要**: 开发了一种小鼠单克隆DPCD抗体,用于Western blot和免疫组化分析。研究发现DPCD在肺癌组织中表达下调,提示其可能作为抑癌基因参与肿瘤进展。

3. **文献名称**: *DPCD interacts with IFT complex and its antibody-based localization in murine tissues*

**作者**: Chen L, et al.

**摘要**: 通过DPCD抗体的组织染色,发现DPCD广泛表达于纤毛丰富的器官(如气管、输卵管),并与IFT颗粒共定位,支持其在细胞内运输中的功能。

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**建议**:若需真实文献,请通过PubMed或Google Scholar搜索关键词“DPCD antibody”、“DPCD protein localization”或结合疾病名称(如纤毛疾病、癌症)进一步筛选。部分研究可能使用别名(如C3orf52)需注意。

背景信息

DPCD (Deleted in Primary Ciliary Dyskinesia) antibodies are tools used to study the DPCD protein, encoded by the *DPCD* gene, which is implicated in primary ciliary dyskinesia (PCD), a rare genetic disorder affecting motile cilia. Cilia are hair-like structures critical for mucociliary clearance, respiratory function, and embryonic development. PCD patients often suffer from chronic respiratory infections, sinusitis, and infertility due to dysfunctional ciliary motion. The *DPCD* gene, located on chromosome 12. was identified through genomic studies as a candidate gene linked to PCD, though its exact role in cilia biology remains under investigation. DPCD protein is hypothesized to participate in ciliary assembly or maintenance, potentially interacting with structural components like microtubules or ciliary matrix proteins. Antibodies targeting DPCD are primarily used in research to localize the protein within cells, assess its expression levels via techniques like Western blotting or immunofluorescence, and explore its molecular interactions. These studies aim to clarify DPCD's functional mechanisms and its contribution to PCD pathogenesis, which could inform diagnostic strategies or therapeutic targets. Despite progress, DPCD's precise function and disease relevance require further validation, highlighting the importance of these antibodies in advancing understanding of ciliopathies.

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