Mouse Monoclonal DPCD Antibody

DPCD (Deleted in Primary Ciliary Dyskinesia) antibodies are tools used to study the DPCD protein, encoded by the *DPCD* gene, which is implicated in primary ciliary dyskinesia (PCD), a rare genetic disorder affecting motile cilia. Cilia are hair-like structures critical for mucociliary clearance, respiratory function, and embryonic development. PCD patients often suffer from chronic respiratory infections, sinusitis, and infertility due to dysfunctional ciliary motion. The *DPCD* gene, located on chromosome 12. was identified through genomic studies as a candidate gene linked to PCD, though its exact role in cilia biology remains under investigation. DPCD protein is hypothesized to participate in ciliary assembly or maintenance, potentially interacting with structural components like microtubules or ciliary matrix proteins. Antibodies targeting DPCD are primarily used in research to localize the protein within cells, assess its expression levels via techniques like Western blotting or immunofluorescence, and explore its molecular interactions. These studies aim to clarify DPCD's functional mechanisms and its contribution to PCD pathogenesis, which could inform diagnostic strategies or therapeutic targets. Despite progress, DPCD's precise function and disease relevance require further validation, highlighting the importance of these antibodies in advancing understanding of ciliopathies.