Mouse Monoclonal KIFBP Antibody

The KIFBP (Kinesin Family Binding Protein) antibody is a research tool designed to detect and study KIFBP, a protein implicated in intracellular transport and cellular dynamics. KIFBP interacts with kinesin motor proteins, particularly those in the Kinesin-1 and Kinesin-3 families, which are essential for microtubule-dependent cargo trafficking. This protein plays a regulatory role in neuronal development, organelle positioning, and synaptic function by modulating kinesin activity or cargo-binding specificity. Dysregulation of KIFBP has been linked to neurodevelopmental disorders and neurodegenerative conditions. Researchers utilize KIFBP antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular models or tissue samples. Recent studies also explore its potential involvement in cancer progression, as altered intracellular transport mechanisms may influence tumor cell invasion. The antibody’s specificity enables the validation of KIFBP knockdown/overexpression models and contributes to structural analyses of kinesin complexes. Ongoing research aims to clarify its precise molecular mechanisms and therapeutic relevance in disease contexts.