Mouse Monoclonal RNF113B Antibody

The RNF113B antibody is a tool used to study the RNF113B protein, a member of the RING finger (Really Interesting New Gene) family characterized by a conserved zinc-binding domain. RNF113B, also known as RAD18-like E3 ubiquitin ligase, is implicated in diverse cellular processes, including transcriptional regulation, RNA processing, and DNA repair. It shares structural homology with RAD18. suggesting potential roles in post-replication DNA repair or nucleotide excision repair (NER). Studies link RNF113B dysfunction to genetic disorders like trichothiodystrophy (TTD), a condition associated with NER defects, and cancer, where altered expression may influence tumor progression. The antibody enables detection and analysis of RNF113B’s expression patterns, interactions, and subcellular localization. It is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its molecular mechanisms. Recent research highlights its involvement in RNA splicing via interactions with spliceosome components, expanding its functional scope. Commercial RNF113B antibodies are typically validated for specificity using knockout cell lines or siRNA silencing. Its study contributes to understanding DNA repair pathways, RNA metabolism, and disease pathogenesis, with potential implications for targeted therapies.