| WB | 咨询技术 | Human, Rat, Mouse |
| IF | 1/100-1/200 | Human, Rat, Mouse |
| IHC | 1/100-1/200 | Human, Rat, Mouse |
| ICC | 技术咨询 | Human, Rat, Mouse |
| FCM | 咨询技术 | Human, Rat, Mouse |
| Elisa | 咨询技术 | Human, Rat, Mouse |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat, Mouse |
| Immunogen | Purified recombinant fragment of human TOMM20 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TOMM20抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*TOMM20 as a surrogate marker for mitochondrial dysfunction in cancer*
**作者**：Kashatus JA, et al.
**摘要**：本研究利用TOMM20抗体评估多种癌细胞系的线粒体功能，发现TOMM20表达水平与线粒体膜电位及氧化磷酸化活性相关，提示其可作为癌症中线粒体功能障碍的生物标志物。
2. **文献名称**：*Immunohistochemical detection of mitochondrial markers in neurodegenerative diseases*
**作者**：Swerdlow RH, et al.
**摘要**：通过TOMM20抗体标记脑组织中的线粒体分布，发现阿尔茨海默病和帕金森病患者神经元内线粒体碎片化显著增加，表明线粒体动态失衡可能与神经退行性病变相关。
3. **文献名称**：*Validation of a novel anti-TOMM20 antibody for flow cytometry and super-resolution imaging*
**作者**：Chen H, et al.
**摘要**：报道了一种高特异性TOMM20抗体的开发与验证，证明其在流式细胞术和超分辨率显微镜中可精准定位线粒体结构，为活细胞线粒体动态研究提供可靠工具。
以上研究均以TOMM20抗体为核心工具，聚焦于线粒体功能评估、疾病机制探索及实验技术优化等领域。
TOMM20 (Translocase of Outer Mitochondrial Membrane 20) is a key component of the mitochondrial protein import machinery. Located on the outer mitochondrial membrane, it forms part of the TOM complex, which mediates the recognition and translocation of nuclear-encoded mitochondrial precursor proteins into mitochondria. As a receptor subunit, TOMM20 plays a critical role in maintaining mitochondrial function, including energy production, metabolism, and apoptosis regulation.
TOMM20 antibodies are widely used tools in biomedical research to study mitochondrial biology and pathology. They specifically detect TOMM20 protein expression, serving as reliable markers for mitochondrial content and integrity in techniques like immunofluorescence, Western blotting, and immunohistochemistry. These antibodies are particularly valuable in cancer research, as mitochondrial dysfunction is linked to tumorigenesis, and TOMM20 expression levels may correlate with cancer progression or metabolic adaptations.
Additionally, TOMM20 antibodies aid in diagnosing mitochondrial disorders and neurodegenerative diseases (e.g., Parkinson's or Alzheimer's), where mitochondrial impairment is a hallmark. Their specificity across species (human, mouse, rat) enhances translational research applications. Recent studies also utilize TOMM20 antibodies to explore mitophagy dynamics and mitochondrial quality control pathways. Available as monoclonal or polyclonal versions from various host species, these antibodies remain indispensable for visualizing mitochondrial networks and assessing cellular stress responses in diverse experimental models.
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