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Mouse Monoclonal ZNF598 Antibody

  • 中文名: ZNF598抗体
  • 别    名: nan
货号: IPDX15501
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ZNF598
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于ZNF598抗体的参考文献示例(注:以下内容为示例性模拟,实际文献请通过学术数据库查询):

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1. **文献名称**: *ZNF598 is a quality control sensor of collided ribosomes*

**作者**: Sundaramoorthy E., et al.

**摘要**: 本研究揭示了ZNF598通过识别翻译过程中停滞的核糖体复合物,并介导其泛素化修饰,进而启动核糖体质量控制通路。研究利用ZNF598抗体进行免疫共沉淀(Co-IP)和蛋白质印迹(Western blot),证实了其与核糖体蛋白的相互作用及泛素化调控功能。

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2. **文献名称**: *ZNF598 regulates ribosome-associated quality control by ubiquitination of rRNA*

**作者**: Juszkiewicz S., Hegde R.S.

**摘要**: 研究通过ZNF598抗体进行细胞定位分析,发现ZNF598在核糖体碰撞时被招募至停滞位点,并通过泛素化修饰18S rRNA,触发mRNA降解。该机制为细胞应对翻译错误提供了分子基础。

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3. **文献名称**: *The E3 ligase ZNF598 suppresses antiviral immunity by targeting RIG-I*

**作者**: Ikeuchi K., et al.

**摘要**: 本文利用ZNF598抗体进行免疫荧光染色和ChIP-seq实验,证明ZNF598通过泛素化修饰天然免疫信号分子RIG-I,负调控抗病毒反应。研究揭示了ZNF598在先天免疫中的新功能。

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4. **文献名称**: *ZNF598 deficiency leads to neurodegeneration via ribosome stalling*

**作者**: Wang T., et al.

**摘要**: 通过在小鼠模型中结合ZNF598抗体进行组织免疫组化分析,研究发现ZNF598缺失导致神经元内核糖体停滞累积,引发蛋白质稳态失衡和神经退行性病变,提示其与神经疾病的潜在关联。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“ZNF598 antibody”或结合研究主题筛选近年论文。

背景信息

The ZNF598 antibody is a crucial tool in studying the role of ZNF598. a zinc finger protein involved in ribosome-associated quality control (RQC) pathways. ZNF598 functions as an E3 ubiquitin ligase that recognizes stalled ribosomes during translation, marking aberrant nascent polypeptides or faulty mRNAs for degradation via ubiquitination. This process is essential for maintaining proteostasis and preventing the accumulation of toxic protein aggregates linked to neurodegenerative diseases and cancer. Researchers employ ZNF598 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions with ribosomes or co-factors like EDF1. Studies have highlighted ZNF598's role in resolving translational stress caused by mRNA truncations, codon repeats, or ribosome collisions, with dysregulation implicated in amyotrophic lateral sclerosis (ALS) and other disorders. The antibody's specificity and validation (e.g., knockout validation) are critical for ensuring accurate detection in diverse experimental models, including cell lines and tissue samples. Its applications span molecular biology, neurobiology, and oncology, particularly in exploring mechanisms of translational fidelity, cellular stress responses, and disease pathogenesis.

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