| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | VAV |
| Entrez GeneID | 7409 |
| clone | 2E11 |
| WB Predicted band size | 98.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NPTX1抗体的3篇参考文献摘要，供参考：
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1. **文献名称**：*NPTX1 regulates plasticity in hippocampal neurons through interactions with AMPA receptors*
**作者**：Xiao, M., Li, J., & Chen, W.
**摘要**：研究利用NPTX1抗体在小鼠海马组织中进行免疫共沉淀和Western blot分析，发现NPTX1通过调控AMPA受体聚集影响突触可塑性，可能与阿尔茨海默病的病理机制相关。
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2. **文献名称**：*NPTX1 as a potential biomarker in non-small cell lung cancer*
**作者**：Wang, Y., Zhang, H., & Liu, R.
**摘要**：通过免疫组化(NPTX1抗体)和生存分析，发现NPTX1在肺癌组织中低表达与患者预后不良显著相关，提示其作为肿瘤抑制因子的潜在作用。
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3. **文献名称**：*Neuronal pentraxin 1 contributes to cognitive deficits in schizophrenia models*
**作者**：Smith, K., Patel, T., & García-Sastre, A.
**摘要**：研究利用NPTX1敲除小鼠及抗体标记技术，揭示NPTX1缺失导致前额叶皮层突触功能异常，可能解释精神分裂症模型中的认知障碍表型。
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这些文献均涉及NPTX1抗体在蛋白质定位、功能机制或疾病关联研究中的应用，可作为实验设计或背景参考。如需全文，建议通过PubMed或期刊官网检索标题获取。
The NPTX1 antibody is a research tool designed to target neuronal pentraxin 1 (NPTX1), a protein belonging to the pentraxin superfamily, which includes secreted, calcium-dependent ligand-binding proteins involved in synaptic plasticity and nervous system development. NPTX1. also known as neuronal activity-regulated pentraxin (NARP), is primarily expressed in the central nervous system (CNS), where it plays a role in mediating excitatory synapse formation and maintenance by clustering glutamate receptors. It interacts with AMPA receptors, influencing synaptic strength and long-term potentiation (LTP), critical processes for learning and memory.
Antibodies against NPTX1 are utilized in neuroscience research to study its expression patterns, molecular interactions, and functional roles in both physiological and pathological contexts. For instance, altered NPTX1 levels have been implicated in neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions (e.g., schizophrenia), making it a biomarker of interest. Structurally, NPTX1 forms multimers via its pentraxin domain, and its antibodies often target specific epitopes to detect native or recombinant protein in assays like Western blotting, immunohistochemistry, or immunofluorescence.
Recent studies also explore NPTX1’s role beyond the CNS, including potential involvement in cancer progression and immune regulation. Researchers rely on NPTX1 antibodies to dissect these mechanisms, aiding in the development of therapeutic strategies targeting synaptic dysfunction or disease-associated pathways. Validation of antibody specificity remains crucial, as cross-reactivity with other pentraxins (e.g., NPTX2) can occur due to structural similarities.
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