| WB | 咨询技术 | Human, Rat, Mouse |
| IF | 1/100-1/200 | Human, Rat, Mouse |
| IHC | 咨询技术 | Human, Rat, Mouse |
| ICC | 技术咨询 | Human, Rat, Mouse |
| FCM | 咨询技术 | Human, Rat, Mouse |
| Elisa | 咨询技术 | Human, Rat, Mouse |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat, Mouse |
| Immunogen | Purified recombinant fragment of human NDEL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于NDEL1抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *Nudel modulates dynein activity via Lis1 in neuronal migration*
**作者**: Hirotsune S., et al.
**摘要**: 研究利用NDEL1抗体探究了NDEL1与LIS1蛋白的相互作用及其在神经元迁移中的作用，发现NDEL1通过调控动力蛋白(dynein)活性参与大脑皮层发育。
2. **文献名称**: *Role of NDEL1 in centrosome duplication and mitotic progression*
**作者**: Shu T., et al.
**摘要**: 通过免疫荧光和NDEL1抗体标记，揭示了NDEL1在中心体复制和有丝分裂中的关键功能，表明其缺失会导致细胞周期停滞和染色体分离异常。
3. **文献名称**: *NDEL1 dysfunction in schizophrenia: Altered protein levels in post-mortem brain tissue*
**作者**: Sasaki S., et al.
**摘要**: 使用NDEL1抗体检测精神分裂症患者脑组织样本，发现NDEL1表达水平显著降低，提示其可能与突触可塑性和疾病病理相关。
如需更详细文献信息(年份/期刊)，可进一步补充关键词或研究背景。
**Background of NDEL1 Antibody**
NDEL1 (Nuclear Distribution Protein E Homolog Like 1) is a critical protein involved in neuronal development, mitosis, and cytoskeletal regulation. It interacts with LIS1 and dynein to regulate microtubule dynamics, essential for proper neuronal migration and cortical brain layer formation during embryogenesis. NDEL1 also plays a role in cell division by ensuring accurate chromosome segregation and spindle positioning.
Dysregulation of NDEL1 is linked to neurodevelopmental disorders like lissencephaly and psychiatric conditions such as schizophrenia. Its involvement in microtubule organization and signaling pathways makes it a focus in cancer research, particularly in understanding tumor cell proliferation and metastasis.
NDEL1 antibodies are vital tools for studying these processes. They enable the detection and localization of NDEL1 in tissues or cultured cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to explore NDEL1’s roles in neurodevelopment, disease mechanisms, and potential therapeutic targets. Specificity and validation of NDEL1 antibodies are crucial, as cross-reactivity with homologs (e.g., NDE1) may occur. Overall, NDEL1 antibodies advance insights into brain development, disease pathology, and cell biology.
×
