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Rat Monoclonal Smc3 Antibody

  • 中文名: Smc3抗体
  • 别    名: nan
货号: IPDX15430
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeRat IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenPurified recombinant fragment of mouse Smc3
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于Smc3抗体的3篇参考文献示例(注:文献为虚构示例,仅供格式参考):

1. **文献名称**:*Smc3 is essential for sister chromatid cohesion in vertebrate cells*

**作者**:Hirano, T., et al.

**摘要**:本研究通过免疫荧光和抗体阻断实验,揭示了Smc3蛋白在脊椎动物细胞姐妹染色单体结合中的核心作用,证实其与Cohesin复合体的其他组分协同维持染色体结构的稳定性。

2. **文献名称**:*Dysregulation of Smc3 expression in colorectal cancer correlates with clinical prognosis*

**作者**:Zhang, Y., et al.

**摘要**:通过免疫组化分析发现,Smc3在结直肠癌组织中异常高表达,且与肿瘤分期和患者生存率显著相关,提示Smc3可能作为潜在的预后生物标志物。

3. **文献名称**:*Smc3 depletion disrupts mitotic progression and induces genomic instability*

**作者**:Watrin, E., et al.

**摘要**:利用Smc3特异性抗体进行功能研究,发现Smc3缺失会导致有丝分裂延迟和染色体错误分离,强调其在维持基因组完整性中的关键角色。

4. **文献名称**:*Structural insights into Smc3 acetylation and its role in cohesin dynamics*

**作者**:Davidson, I.F., et al.

**摘要**:通过结构生物学和抗体标记技术,解析了Smc3乙酰化修饰对其在Cohesin复合体中动态调控的影响,为理解染色体分离机制提供新视角。

(注:以上文献为模拟示例,实际文献需通过PubMed/Google Scholar等平台检索确认。)

背景信息

The SMC3 (Structural Maintenance of Chromosomes 3) antibody is a crucial tool for studying the cohesin complex, a multi-subunit protein assembly essential for chromosome organization and genomic stability. SMC3. a core component of cohesin, forms a V-shaped heterodimer with SMC1. stabilized by STAG and RAD21 subunits. This complex mediates sister chromatid cohesion during mitosis and meiosis, ensuring accurate chromosome segregation. Beyond its role in cell division, cohesin regulates DNA repair, transcription, and chromatin looping. Dysregulation of SMC3 is linked to developmental disorders (e.g., Cornelia de Lange syndrome) and cancers, particularly those with chromosomal instability. Antibodies targeting SMC3 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation. They are vital for exploring cohesin's mechanistic roles in 3D genome architecture and disease pathogenesis. Commercially available SMC3 antibodies are typically validated across human, mouse, and rat models, supporting diverse experimental applications in epigenetics and cancer biology research.

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