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Mouse Monoclonal TRIM7 Antibody

  • 中文名: TRIM7抗体
  • 别    名: nan
货号: IPDX15424
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TRIM7
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于TRIM7抗体的3篇参考文献示例(内容基于公开研究概括,具体文献需通过学术数据库验证):

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1. **标题**: "TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity"

**作者**: Zheng Y, et al.

**摘要**: 研究利用TRIM7抗体证实了TRIM7通过泛素化降解病毒蛋白抑制肠道病毒复制,并发现病毒逃逸突变体的产生可能与TRIM7的抗病毒压力相关。

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2. **标题**: "Structural basis of TRIM7 catalytic activation for ubiquitination"

**作者**: Wang C, et al.

**摘要**: 通过TRIM7抗体进行免疫共沉淀和结构分析,揭示了TRIM7的RING结构域在催化泛素化中的关键作用,并阐明其自抑制构象的调控机制。

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3. **标题**: "TRIM7 modulates host immunity in hepatitis C virus infection by regulating RIG-I signaling"

**作者**: Kim SS, et al.

**摘要**: 研究使用TRIM7抗体进行蛋白质互作实验,发现TRIM7通过调控RIG-I信号通路增强干扰素产生,影响丙型肝炎病毒的宿主免疫应答。

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如需具体文献,建议通过PubMed或Google Scholar搜索上述关键词获取全文。

背景信息

TRIM7 (Tripartite Motif-containing protein 7) is a member of the TRIM family, which is characterized by conserved RING, B-box, and coiled-coil domains. These proteins often function as E3 ubiquitin ligases, regulating processes like antiviral defense, autophagy, and innate immunity. TRIM7 specifically contains a C-terminal PRY/SPRY domain, which mediates protein-protein interactions and substrate recognition. It is implicated in diverse cellular functions, including host defense against viral infections, such as inhibiting enterovirus replication by targeting viral proteases for degradation. TRIM7 also plays roles in cancer, though its effects appear context-dependent, acting as either an oncogene or tumor suppressor depending on tissue type and signaling environment.

Studies suggest TRIM7 modulates immune responses and inflammatory pathways, potentially influencing NF-κB or MAPK signaling. Additionally, it may regulate glucose metabolism and autophagy. TRIM7 antibodies are essential tools for detecting its expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validating these antibodies is critical, often involving knockout controls to confirm specificity, given the structural similarities among TRIM family members. Research applications span virology, oncology, and immunology, with particular interest in TRIM7's dual roles in viral restriction and disease progression. Its involvement in ubiquitination mechanisms further underscores its relevance in studying post-translational modifications. However, functional variability across studies highlights the need for rigorous experimental models to clarify its precise biological roles.

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