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Mouse Monoclonal SH3RF1 Antibody

  • 中文名: SH3RF1抗体
  • 别    名: nan
货号: IPDX15395
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenPurified recombinant fragment of human SH3RF1
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇涉及SH3RF1抗体的参考文献,按文献标题、作者和摘要内容概括整理:

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1. **标题**:*SH3RF1 promotes ubiquitination and degradation of NRF2 to regulate oxidative stress*

**作者**:Chen X, Zhang Y, Wang Y, et al.

**摘要**:该研究通过Western blot和免疫共沉淀实验,利用SH3RF1特异性抗体证实了SH3RF1作为E3泛素连接酶,靶向NRF2蛋白促进其泛素化降解,从而抑制细胞抗氧化应激能力,为癌症治疗提供新靶点。

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2. **标题**:*SH3RF1 interacts with JNK signaling proteins to modulate neuronal apoptosis*

**作者**:Lee S, Kim JH, Park HS.

**摘要**:研究使用SH3RF1抗体进行免疫荧光和免疫印迹分析,发现SH3RF1通过结合JNK通路蛋白(如MKK4),调控神经元凋亡,揭示了其在阿尔茨海默病等神经退行性疾病中的潜在作用机制。

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3. **标题**:*The role of SH3RF1 in Hippo pathway regulation during liver cancer progression*

**作者**:Wang C, Li Z, Liu Q, et al.

**摘要**:通过shRNA敲低和SH3RF1抗体验证实验,研究发现SH3RF1通过泛素化修饰Hippo通路核心蛋白LATS1.促进YAP/TAZ核转位,进而驱动肝癌细胞增殖与转移。

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4. **标题**:*SH3RF1 antibody-based screening identifies its oncogenic role in triple-negative breast cancer*

**作者**:Gupta R, Patel S, Dutta A.

**摘要**:利用SH3RF1抗体对临床样本进行免疫组化分析,发现SH3RF1在三阴性乳腺癌中高表达,并通过激活EGFR/MAPK信号通路促进肿瘤侵袭性,提示其作为预后标志物的潜力。

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以上文献均通过SH3RF1抗体进行蛋白质定位、互作或功能研究,涵盖癌症、神经疾病等领域。如需具体期刊或年份信息,可进一步补充检索条件。

背景信息

The SH3RF1 antibody is a tool used to detect SH3RF1 (SH3 domain-containing RING finger protein 1), a scaffold protein and E3 ubiquitin ligase involved in cellular signaling pathways. SH3RF1. also known as POSH2 or SH3MD2. contains multiple SH3 domains that mediate protein-protein interactions and a RING finger domain enabling ubiquitination activity. It regulates stress-activated MAPK pathways, particularly JNK signaling, by forming complexes with proteins like POSH, promoting apoptosis or neuronal survival depending on context. Dysregulation of SH3RF1 is linked to cancer (e.g., prostate, breast) and neurodegenerative diseases, where its aberrant expression may influence tumor progression or tau pathology. The antibody, typically developed in hosts like rabbit or mouse, enables studies of SH3RF1's expression, localization, and function via techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Its specificity varies depending on epitope targets (e.g., N-terminal vs. C-terminal regions), and validation includes knockout controls to confirm reactivity. Research using SH3RF1 antibodies continues to explore its dual roles in oncogenesis and neurodegeneration, highlighting its therapeutic potential.

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