Mouse Monoclonal SH3RF1 Antibody

The SH3RF1 antibody is a tool used to detect SH3RF1 (SH3 domain-containing RING finger protein 1), a scaffold protein and E3 ubiquitin ligase involved in cellular signaling pathways. SH3RF1. also known as POSH2 or SH3MD2. contains multiple SH3 domains that mediate protein-protein interactions and a RING finger domain enabling ubiquitination activity. It regulates stress-activated MAPK pathways, particularly JNK signaling, by forming complexes with proteins like POSH, promoting apoptosis or neuronal survival depending on context. Dysregulation of SH3RF1 is linked to cancer (e.g., prostate, breast) and neurodegenerative diseases, where its aberrant expression may influence tumor progression or tau pathology. The antibody, typically developed in hosts like rabbit or mouse, enables studies of SH3RF1's expression, localization, and function via techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Its specificity varies depending on epitope targets (e.g., N-terminal vs. C-terminal regions), and validation includes knockout controls to confirm reactivity. Research using SH3RF1 antibodies continues to explore its dual roles in oncogenesis and neurodegeneration, highlighting its therapeutic potential.