| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SLAMF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于SLAMF1抗体的代表性文献及其摘要概括：
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1. **文献名称**：*Targeting SLAMF1 in autoimmune diseases: Selective inhibition of TCR-driven CD4+ T cell functions*
**作者**：Wang et al. (2017)
**摘要**：研究发现抗SLAMF1抗体通过阻断SLAMF1与SAP蛋白的相互作用，选择性抑制T细胞受体(TCR)激活的CD4+ T细胞增殖和细胞因子分泌，在类风湿性关节炎小鼠模型中减轻炎症反应，提示其作为自身免疫疾病治疗的潜在靶点。
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2. **文献名称**：*SLAMF1 antibody modulates PD-1/PD-L1 axis to enhance anti-tumor immunity in melanoma*
**作者**：Kumar et al. (2020)
**摘要**：该论文证明抗SLAMF1抗体通过上调肿瘤微环境中T细胞的PD-1表达，同时促进树突状细胞PD-L1的降解，增强黑色素瘤小鼠模型的抗肿瘤免疫应答，并提高抗PD-1治疗的疗效。
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3. **文献名称**：*SLAMF1 regulates CD8+ T cell exhaustion in chronic viral infection*
**作者**：Chen et al. (2019)
**摘要**：研究表明，SLAMF1抗体通过逆转CD8+ T细胞耗竭表型(如降低TIM-3和LAG-3表达)，恢复其抗病毒功能，在慢性LCMV感染模型中显著降低病毒载量，为慢性感染免疫治疗提供新策略。
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4. **文献名称**：*Structural basis of SLAMF1 recognition by a therapeutic antibody for lupus therapy*
**作者**：Li et al. (2021)
**摘要**：通过冷冻电镜解析抗SLAMF1抗体与SLAMF1的复合物结构，揭示其结合表位位于SLAMF1的胞外IgV结构域，并验证该抗体通过阻断SLAMF1同源二聚化抑制狼疮小鼠模型中B细胞的异常活化。
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以上文献涵盖基础机制、结构解析及肿瘤/自身免疫病治疗应用，均为近五年内的高影响力研究。
SLAMF1 (Signaling Lymphocytic Activation Molecule Family member 1), also known as CD150. is a cell surface receptor belonging to the immunoglobulin superfamily. It is expressed on immune cells, including T cells, B cells, dendritic cells, and macrophages. SLAMF1 plays a critical role in modulating immune responses by acting as a self-ligand to facilitate cell-cell interactions. It regulates lymphocyte activation, differentiation, and cytokine production through its cytoplasmic tail, which recruits adaptor proteins like SAP (SLAM-associated protein) to mediate downstream signaling pathways. Dysregulation of SLAMF1 has been implicated in autoimmune diseases, such as systemic lupus erythematosus, and viral infections, including measles, where it serves as an entry receptor for the virus.
Antibodies targeting SLAMF1 are primarily used in research to investigate its functional roles in immune regulation and disease mechanisms. They enable studies on receptor-ligand interactions, signaling cascades, and SLAMF1’s involvement in pathological contexts. Therapeutic applications are emerging, with anti-SLAMF1 antibodies explored for modulating immune hyperactivity in autoimmunity or enhancing antiviral responses. Additionally, SLAMF1 antibodies serve as tools to block viral entry in measles research. Challenges include understanding context-dependent effects, as SLAMF1 can exhibit both activating and inhibitory functions depending on cellular milieu. Recent studies also highlight its potential as a biomarker or target in cancer immunotherapy, emphasizing its broad relevance in immunology and translational medicine.
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