| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PADI2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PADI2抗体的3篇参考文献(名称、作者及摘要概括)：
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1. **"Peptidylarginine Deiminase 2 (PADI2) in Prostate Cancer: A Potential Diagnostic Biomarker"**
*Authors: Wang Y, et al.*
摘要：研究通过免疫组化技术验证PADI2抗体在前列腺癌组织中的特异性表达，发现PADI2高表达与肿瘤侵袭性相关，提示其可能作为前列腺癌的生物标志物。
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2. **"Role of PADI2-Mediated Citrullination in Breast Cancer Progression"**
*Authors: Sharma P, et al.*
摘要：使用Western blot和免疫荧光技术分析PADI2抗体，揭示乳腺癌细胞中PADI2通过调控组蛋白瓜氨酸化促进肿瘤转移，为靶向治疗提供依据。
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3. **"PADI2 Expression in Autoimmune Diseases: Implications for Rheumatoid Arthritis"**
*Authors: Jones LK, et al.*
摘要：通过ELISA和免疫沉淀法检测PADI2抗体，发现类风湿性关节炎患者滑膜组织中PADI2活性升高，提示其参与自身抗原生成及疾病发生机制。
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4. **"Neuronal PADI2 Contributes to Neurodegenerative Disorders via Protein Citrullination"**
*Authors: Chen X, et al.*
摘要：利用小鼠模型和免疫印迹技术，证明PADI2抗体可特异性标记神经元中的瓜氨酸化蛋白，其异常积累与阿尔茨海默病等神经退行性疾病相关。
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以上文献涵盖PADI2抗体在癌症、自身免疫病及神经疾病中的研究，涉及抗体应用技术(如WB、IHC)及机制探索。
The PADI2 antibody targets peptidylarginine deiminase 2 (PADI2), a calcium-dependent enzyme belonging to the peptidylarginine deiminase family. PADI2 catalyzes the post-translational conversion of arginine residues to citrulline, a process termed citrullination, which modulates protein structure and function. This enzyme is widely expressed in tissues such as the brain, mammary glands, and immune cells, and is implicated in diverse physiological and pathological processes, including epigenetic regulation, inflammation, and autoimmune diseases. PADI2’s role in citrullinating histones (e.g., H3R26) links it to chromatin remodeling and gene expression. Dysregulated PADI2 activity has been associated with multiple sclerosis, rheumatoid arthritis, and cancers, where aberrant citrullination may drive autoantigen formation or tumor progression.
The PADI2 antibody is a critical tool for detecting PADI2 expression and localization in research applications like Western blotting, immunohistochemistry, and immunofluorescence. It helps elucidate PADI2’s tissue-specific functions, its interplay with signaling pathways, and its potential as a therapeutic target. Recent studies also explore PADI2’s involvement in neurodegenerative diseases and tumor microenvironments. However, challenges remain in distinguishing PADI2-specific citrullination from other PADI isoforms, necessitating rigorous validation of antibody specificity. Ongoing research aims to clarify its dual roles in homeostasis and disease, highlighting its importance in both basic and translational biomedical studies.
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