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Mouse Monoclonal GAL Antibody

  • 中文名: GAL抗体
  • 别    名: nan
货号: IPDX15352
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GAL
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于GAL抗体的3篇参考文献示例(内容基于领域内常见研究方向,仅供参考):

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1. **"Galanin expression in neuropathological states: A review"**

*作者:Hökfelt, T. et al.*

**摘要**:综述galanin(GAL)在中枢神经系统疾病(如阿尔茨海默病、癫痫)中的表达变化,强调GAL抗体的免疫组化应用,揭示其与神经元损伤和修复的关联。

2. **"Validation of a novel galanin-3 receptor antibody for studying autonomic nervous system disorders"**

*作者:Lang, R. et al.*

**摘要**:研究通过Western blot和免疫荧光验证GALR3抗体的特异性,证明其在自主神经节中的高表达,为研究代谢疾病提供工具。

3. **"Galanin modulates neuropathic pain via microglial activation in a rat model"**

*作者:Xu, Z. et al.*

**摘要**:使用GAL抗体阻断实验,发现galanin通过小胶质细胞激活加剧神经性疼痛,提示靶向GAL信号或为镇痛治疗新策略。

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*注:以上文献为模拟示例,实际引用建议通过PubMed或Google Scholar检索确认。*

背景信息

GAL antibodies primarily target the galactose-α-1.3-galactose (α-Gal) epitope, a carbohydrate structure found on glycoproteins and glycolipids of non-primate mammals. This epitope is absent in humans due to the evolutionary inactivation of the α-1.3-galactosyltransferase gene. Anti-GAL antibodies, particularly IgE and IgG subtypes, have gained attention for their role in allergic reactions and immune responses. IgE anti-GAL antibodies are linked to alpha-gal syndrome, a delayed allergic reaction to red meat and dairy products, triggered by tick bites (e.g., Lone Star tick) that sensitize individuals to α-Gal. IgG anti-GAL antibodies are implicated in transplant rejection, especially in xenotransplantation, as porcine tissues express α-Gal, leading to hyperacute rejection. Additionally, anti-GAL antibodies may influence autoimmune diseases and cancer immunity. Research explores their diagnostic utility in allergy testing and therapeutic strategies, such as genetically engineered α-Gal-free organs for transplantation. Understanding GAL antibodies bridges immunology, allergology, and translational medicine, addressing challenges in food allergies, xenotransplantation, and immune-mediated disorders.

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