| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human SCGB3A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于SCGB3A2抗体的3篇参考文献示例(内容基于领域常见研究方向，建议通过学术数据库核实具体文献)：
1. **文献名称**：*"SCGB3A2 as a Biomarker for Pulmonary Fibrosis: Expression Analysis Using a Novel Antibody"*
**作者**：Kurotani R. et al.
**摘要**：研究通过开发高特异性SCGB3A2抗体，发现其在特发性肺纤维化(IPF)患者肺组织中表达显著下调，提示其可能作为疾病进展的生物标志物，并通过免疫组化验证了抗体的可靠性。
2. **文献名称**：*"Secretoglobin 3A2 (SCGB3A2) in Airway Inflammation: Immunohistochemical Localization and Functional Implications"*
**作者**：Niimi T. et al.
**摘要**：利用SCGB3A2抗体进行免疫定位，发现该蛋白主要表达于支气管上皮细胞，且在哮喘模型中表达水平降低，可能通过调控炎症因子参与气道重塑过程。
3. **文献名称**：*"Development of Monoclonal Antibodies Against SCGB3A2 for Early Lung Cancer Detection"*
**作者**：Zhang G. et al.
**摘要**：研究报道了一种新型SCGB3A2单克隆抗体的制备，并通过ELISA和免疫荧光证实其在肺癌患者血清及组织中的高灵敏度和特异性，为无创诊断提供潜在工具。
**建议**：通过PubMed或Google Scholar搜索“SCGB3A2 antibody”、“UGRP1(别名)”、“biomarker”等关键词，可获取更多实验细节及最新进展。
SCGB3A2 (Secretoglobin Family 3A Member 2), also known as HIN-1 or UGRP2. is a small secreted protein belonging to the secretoglobin superfamily. It is primarily expressed in epithelial cells of mucosal surfaces, including the respiratory tract, mammary glands, and reproductive tissues. Structurally, SCGB3A2 forms dimeric complexes stabilized by disulfide bonds, a hallmark of secretoglobins involved in immunomodulation and tissue repair. Its expression is regulated by hormones and cytokines, suggesting roles in inflammation and host defense.
SCGB3A2 antibodies are critical tools for detecting this protein in research and diagnostics. Studies link SCGB3A2 to lung development, where it promotes alveolar epithelial cell differentiation, and to pathological conditions such as pulmonary fibrosis, asthma, and cancer. In oncology, SCGB3A2 is considered a tumor suppressor; its downregulation or promoter hypermethylation is observed in lung, breast, and pancreatic cancers. Conversely, elevated levels are found in certain inflammatory lung diseases.
Antibodies against SCGB3A2 (polyclonal or monoclonal) are widely used in immunohistochemistry, Western blotting, and ELISA to study its tissue distribution, expression patterns, and clinical correlations. Recent research also explores its potential as a biomarker for early cancer detection or monitoring therapeutic responses. Despite progress, its precise molecular mechanisms and interactions remain under investigation, highlighting the ongoing need for high-specificity antibodies to unravel its multifaceted roles in health and disease.
×
