WB | 咨询技术 | Human,Mouse,Rat |
IF | 1/100-1/200 | Human,Mouse,Rat |
IHC | 1/100-1/200 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human AMBP |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于AMBP抗体的3篇参考文献及其摘要概括:
1. **文献名称**: *Alpha-1-microglobulin/bikunin precursor (AMBP) is a novel inhibitor of angiogenesis*
**作者**: Olsson MG et al.
**摘要**: 该研究发现AMBP通过其结构域抑制血管内皮生长因子(VEGF)介导的血管生成,实验利用AMBP抗体证实其在肿瘤微环境中的表达下调,提示其作为抗肿瘤治疗的潜在靶点。
2. **文献名称**: *Urinary AMBP levels correlate with acute kidney injury progression and mortality in critically ill patients*
**作者**: Zhang Z et al.
**摘要**: 研究通过ELISA和Western blot(使用AMBP抗体)检测重症患者尿液AMBP水平,发现其与急性肾损伤严重程度及死亡率显著相关,提出AMBP可作为早期生物标志物。
3. **文献名称**: *AMBP modulates the immune response in sepsis by regulating complement activation*
**作者**: Li Y et al.
**摘要**: 利用基因敲除小鼠和AMBP抗体实验,证明AMBP通过抑制补体过度激活减轻脓毒症炎症反应,提示靶向AMBP可能改善脓毒症患者的免疫失衡。
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**注**:以上文献信息为模拟示例,实际引用需以具体论文数据为准。建议通过PubMed或Web of Science以“AMBP antibody”及关联关键词检索最新研究。
The Alpha-1-Microglobulin/Bikunin Precursor (AMBP) protein is a liver-synthesized glycoprotein that undergoes proteolytic cleavage to generate two functional subunits: alpha-1-microglobulin (A1M) and bikunin. A1M exhibits antioxidant and immunomodulatory properties, binding heme and reactive oxygen species, while bikunin, a serine protease inhibitor, regulates inflammation by inhibiting enzymes like trypsin and plasmin. Both subunits are involved in extracellular matrix maintenance and stress response pathways.
AMBP antibodies are essential tools for detecting and quantifying these subunits in research and diagnostics. They enable the study of AMBP's roles in diseases such as chronic kidney disease, sepsis, and cancer, where altered expression or dysfunction is observed. For example, urinary A1M and bikunin levels are biomarkers for kidney injury, while bikunin's anti-metastatic effects are explored in oncology. Antibodies specific to AMBP or its cleavage products are used in techniques like ELISA, Western blot, and immunohistochemistry to assess protein localization, expression dynamics, and post-translational modifications. Their development emphasizes specificity to distinguish between isoforms or modified forms, ensuring accurate biological insights. Clinically, AMBP antibodies aid in diagnosing pathological states or monitoring therapeutic interventions targeting inflammation or oxidative stress pathways.
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