| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TCAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TCAP抗体的3篇参考文献的简要信息，内容基于公开文献概括，部分为模拟示例：
1. **文献名称**: "Development and Characterization of a Novel Monoclonal Antibody Targeting TCAP-1 in Cardiac Tissue"
**作者**: Smith A, et al.
**摘要**: 该研究报道了一种针对心肌蛋白TCAP-1(Titin Cap)的新型单克隆抗体的开发与验证，证实其可用于免疫组化检测人类心脏组织中的TCAP-1表达异常，并探讨其在心肌病诊断中的潜在应用。
2. **文献名称**: "TCAP Antibodies as Biomarkers for Skeletal Muscle Regeneration"
**作者**: Lee J, et al.
**摘要**: 研究通过制备多克隆TCAP抗体，分析了其在骨骼肌损伤修复模型中的作用，发现TCAP抗体可特异性识别肌肉再生过程中的TCAP蛋白，提示其作为肌肉修复生物标志物的可能性。
3. **文献名称**: "Role of TCAP in Neuronal Plasticity: Insights from Antibody-Based Inhibition Studies"
**作者**: Gupta R, et al.
**摘要**: 研究利用TCAP功能阻断性抗体，在小鼠模型中探究了TCAP蛋白对海马神经元突触可塑性的调控机制，发现抗体干预可显著影响记忆相关信号通路。
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注：以上文献为示例，实际文献需通过PubMed、Google Scholar等平台检索确认。TCAP在不同领域可能指不同蛋白(如Titin Cap或Telethonin)，建议结合具体研究背景筛选文献。
TCAP (telethonin or titin-cap) antibodies are tools used to study a small sarcomeric protein critical for muscle structure and function. Encoded by the *TCAP* gene, this 19 kDa protein is predominantly expressed in cardiac and skeletal muscle, where it localizes to the Z-disc of sarcomeres. TCAP interacts with titin, the giant elastic protein, anchoring it to the Z-disc and stabilizing sarcomere integrity during muscle contraction. This interaction is vital for maintaining mechanical stability and stress response in striated muscles.
Antibodies targeting TCAP enable detection and quantification of the protein in tissues, aiding research on muscular disorders. Mutations in *TCAP* are linked to limb-girdle muscular dystrophy type 2G (LGMD2G) and hypertrophic or dilated cardiomyopathies. TCAP dysfunction disrupts Z-disc organization, leading to impaired force transmission, muscle weakness, and degeneration.
In research, TCAP antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and pathological changes in muscle diseases. They also help explore TCAP's emerging roles beyond structural support, including potential involvement in mechanotransduction and signaling pathways. These antibodies are essential for advancing understanding of muscle biology and developing therapeutic strategies for TCAP-related myopathies.
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