| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CCL7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇涉及CCL7抗体的参考文献概览：
1. **标题**: *CCL7 recruits DCs to promote tumor immunity via enhancing T cell priming and overcoming checkpoint blockade resistance*
**作者**: Smith A, et al.
**摘要**: 该研究利用抗CCL7抗体阻断小鼠肿瘤模型中的CCL7信号，发现CCL7通过招募树突状细胞(DCs)增强T细胞活化，抑制CCL7会削弱免疫检查点抑制剂的抗肿瘤效果，提示CCL7抗体在联合免疫治疗中的潜在应用。
2. **标题**: *Neutralization of CCL7 ameliorates ischemia-reperfusion injury after liver transplantation in mice*
**作者**: Zhang Y, et al.
**摘要**: 研究使用抗CCL7抗体干预小鼠肝移植缺血再灌注损伤模型，发现抑制CCL7可减少中性粒细胞浸润和炎症因子释放，显著改善肝组织损伤，表明靶向CCL7可能成为器官移植后并发症的治疗策略。
3. **标题**: *CCL7 modulates bone metastasis of breast cancer via mediating osteoclast differentiation*
**作者**: Lee H, et al.
**摘要**: 通过抗CCL7抗体阻断实验，作者揭示乳腺癌分泌的CCL7通过激活破骨细胞分化促进骨转移，抗体干预后显著减少小鼠模型中骨破坏病灶，为乳腺癌骨转移提供了新的治疗靶点。
4. **标题**: *CCL7 as a biomarker in neuroinflammatory diseases: Insights from CSF analysis*
**作者**: Müller-Lenke N, et al.
**摘要**: 该研究利用抗CCL7抗体检测多发性硬化患者脑脊液中CCL7水平，发现其与疾病活动度正相关，提示CCL7可作为神经炎症疾病进展的生物标志物及潜在治疗靶标。
注：以上文献信息为示例性内容，实际文献需通过PubMed或Web of Science等数据库检索确认。
The CCL7 antibody is a research tool designed to detect and analyze CCL7 (Chemokine (C-C motif) ligand 7), a small secreted protein belonging to the CC chemokine family. CCL7. also known as monocyte chemoattractant protein-3 (MCP-3), plays a critical role in immune regulation by recruiting monocytes, eosinophils, dendritic cells, and T-cells to sites of inflammation or injury. It binds to multiple chemokine receptors, including CCR1. CCR2. and CCR3. facilitating immune cell migration and activation.
CCL7 antibodies are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to quantify protein expression, localize cellular sources, or study its involvement in disease mechanisms. Research has linked CCL7 to pathological conditions such as cancer metastasis (e.g., promoting tumor-associated macrophage infiltration in breast cancer), chronic inflammatory diseases (e.g., rheumatoid arthritis), and viral infections (e.g., HIV, where it may interfere with viral entry).
Antibodies targeting CCL7 are available in monoclonal or polyclonal forms, often validated for specificity and sensitivity. Neutralizing antibodies are particularly valuable for blocking CCL7-receptor interactions in functional studies to dissect signaling pathways. Recent studies also explore its potential as a therapeutic target or biomarker in inflammatory and oncological contexts. Understanding CCL7's role through antibody-based assays continues to advance both basic immunology and translational research.
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