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Mouse Monoclonal NEDD4 Antibody

  • 中文名: NEDD4抗体
  • 别    名: nan
货号: IPDX15279
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human NEDD4
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于NEDD4抗体的3篇参考文献示例(注:文献信息为虚构示例,仅供格式参考):

1. **《NEDD4-specific monoclonal antibody generation and application in cancer cell analysis》**

*作者:Zhang L, et al.*

摘要:本研究开发了一种高特异性的NEDD4单克隆抗体,通过免疫印迹和免疫组化验证其在多种癌细胞系中的表达,证实其在肿瘤中异常上调并与EGFR降解相关。

2. **《Role of NEDD4 in neuronal development revealed by antibody-mediated inhibition》**

*作者:Kim S, et al.*

摘要:利用抗NEDD4抗体阻断其泛素连接酶活性,发现NEDD4通过调控突触蛋白泛素化影响神经元突触形成,为神经发育障碍研究提供新方向。

3. **《Antibody-based detection of NEDD4 isoforms in cardiovascular tissues》**

*作者:Wang Y, et al.*

摘要:通过定制多克隆抗体识别NEDD4不同剪接变体,揭示其在心肌细胞中的亚细胞定位差异,并发现其与心脏肥大信号通路的关联。

(注:实际文献需通过PubMed或学术数据库检索,建议结合具体研究目标筛选。)

背景信息

The NEDD4 (Neuronal Precitor Cell-Expressed Developmentally Downregulated 4) antibody is a critical tool for studying the NEDD4 family of E3 ubiquitin ligases, which play pivotal roles in protein ubiquitination and degradation. NEDD4. a member of the HECT-domain E3 ligase family, regulates cellular processes such as membrane receptor trafficking, apoptosis, and cell proliferation by tagging target proteins (e.g., PTEN, EGFR, and Notch) with ubiquitin for proteasomal or lysosomal degradation. Its structure includes a C2 domain (mediating membrane binding), multiple WW domains (substrate recognition), and a catalytic HECT domain. Dysregulation of NEDD4 is implicated in cancers, neurological disorders (e.g., Alzheimer’s and Parkinson’s), and hypertension. Researchers employ NEDD4 antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate its expression, interaction partners, and subcellular localization. These antibodies help elucidate NEDD4’s role in disease mechanisms and validate its potential as a therapeutic target. Specificity validation (via knockout controls) and cross-reactivity checks are essential due to homology among NEDD4 family members (NEDD4-1. NEDD4-2. etc.).

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