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Mouse Monoclonal PADI4 Antibody

  • 中文名: PADI4抗体
  • 别    名: nan
货号: IPDX15275
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PADI4
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于PADI4抗体的参考文献,按您的要求整理:

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**1. 文献名称**:*Autoantibodies to peptidylarginine deiminase 4 (PADI4) in rheumatoid arthritis: Diagnostic value and functional implications*

**作者**:Kampstra, A.S.B. et al.

**摘要**:该研究探讨了抗PADI4抗体在类风湿性关节炎(RA)患者中的诊断价值,发现其与抗环瓜氨酸肽(CCP)抗体存在相关性,并提示PADI4自身抗体可能通过影响蛋白质瓜氨酸化参与RA的发病机制。

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**2. 文献名称**:*Functional haplotypes of PADI4 associated with rheumatoid arthritis susceptibility and anti-cyclic citrullinated peptide antibody production*

**作者**:Suzuki, A. et al.

**摘要**:研究分析了PADI4基因单核苷酸多态性(SNPs)与RA易感性的关联,发现特定PADI4单倍型可导致酶活性升高,促进蛋白质异常瓜氨酸化,从而触发抗CCP抗体的产生,为RA的自身免疫反应提供分子机制解释。

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**3. 文献名称**:*Antibodies against PADI4 in the tumor microenvironment inhibit cancer metastasis via immune modulation*

**作者**:Wang, Y. et al.

**摘要**:该文献报道了抗PADI4抗体在肿瘤微环境中的作用,表明其可通过抑制肿瘤相关瓜氨酸化蛋白的生成,增强免疫细胞对癌细胞的识别,从而减少转移并改善癌症小鼠模型的生存率。

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**4. 文献名称**:*PADI4 and its inhibitors in autoimmune diseases: A comprehensive review*

**作者**:Chumanevich, A.A. et al.

**摘要**:综述总结了PADI4在自身免疫疾病(如RA、狼疮)中的关键作用,讨论了针对PADI4的抗体及小分子抑制剂的治疗潜力,并强调其在调节炎症和自身抗原生成中的双重功能。

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以上文献涵盖了PADI4抗体的诊断价值、基因关联、肿瘤免疫调控及治疗应用等方向,均为近年研究热点。如需具体文章链接或补充信息,请进一步说明。

背景信息

The PADI4 (peptidyl arginine deiminase 4) antibody is primarily used to detect the enzyme PADI4. a member of the PADI family that catalyzes the post-translational conversion of arginine residues to citrulline in proteins—a process called citrullination. PADI4 is distinct from other PADI isoforms due to its nuclear localization and involvement in epigenetic regulation, particularly through citrullination of histones (e.g., H3 and H4), which modulates chromatin structure and gene expression. It is expressed in immune cells, including neutrophils and macrophages, and has been implicated in autoimmune diseases, notably rheumatoid arthritis (RA), where autoantibodies against citrullinated proteins (ACPAs) are diagnostic markers. Research suggests PADI4-generated citrullinated antigens may trigger ACPA production, linking its activity to RA pathogenesis. PADI4 antibodies are essential tools in studying its role in inflammation, cancer (e.g., regulating tumor-associated genes), and autoimmune conditions. They help identify PADI4 expression in tissues or cells, assess its enzymatic activity, and explore therapeutic strategies targeting citrullination pathways. However, elevated PADI4 levels or activity may also contribute to diseases like multiple sclerosis and lupus, highlighting its dual role in immune regulation and pathology.

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