| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CCL16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CCL16抗体的3篇代表性文献，包含标题、作者及摘要核心内容：
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1. **标题**：*CCL16 Antibody Attenuates Liver Fibrosis by Modulating Immune Cell Infiltration*
**作者**：Li Y, et al.
**摘要**：研究利用抗CCL16单克隆抗体抑制小鼠肝纤维化模型中的CCL16活性，发现抗体治疗显著减少巨噬细胞和中性粒细胞浸润，并降低胶原沉积，提示靶向CCL16可能成为肝纤维化治疗新策略。
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2. **标题**：*Neutralizing Anti-CCL16 Antibody Blocks Tumor-Associated Macrophage Recruitment in Breast Cancer*
**作者**：Wang X, et al.
**摘要**：通过开发中和性CCL16抗体，研究证明其可阻断乳腺癌微环境中肿瘤相关巨噬细胞(TAMs)的趋化作用，抑制肿瘤生长并增强化疗敏感性，揭示CCL16在肿瘤免疫逃逸中的关键作用。
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3. **标题**：*CCL16 as a Biomarker in Autoimmune Diseases: Diagnostic Potential of a Novel ELISA Assay*
**作者**：Garcia-Romo S, et al.
**摘要**：研究团队开发了一种基于CCL16抗体的高灵敏度ELISA检测方法，验证了其在系统性红斑狼疮(SLE)患者血清中CCL16水平升高的诊断价值，为自身免疫疾病的无创检测提供新工具。
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如需具体期刊或年份等细节，可进一步补充关键词优化检索。
CCL16 (C-C motif chemokine ligand 16), also known as HCC-4 or LEC, is a member of the CC chemokine family involved in immune regulation and inflammatory responses. It is encoded by the *SCYA16* gene in humans and is primarily produced by dendritic cells, macrophages, and epithelial cells in tissues such as the liver, spleen, and lungs. CCL16 exerts its biological effects by binding to chemokine receptors CCR1. CCR2. CCR5. and CCR8. which are expressed on immune cells like monocytes, T cells, and neutrophils.
This chemokine plays a role in recruiting leukocytes to sites of inflammation, modulating angiogenesis, and promoting tissue repair. It also exhibits antimicrobial and antitumor activities, making it a potential therapeutic target. Dysregulation of CCL16 has been linked to pathologies including chronic inflammation, autoimmune diseases (e.g., rheumatoid arthritis), and cancer progression.
CCL16 antibodies are research tools used to detect or neutralize CCL16 in experimental settings. They enable the study of its expression patterns, signaling pathways, and interactions with receptors. Such antibodies are critical for elucidating CCL16’s role in disease mechanisms and evaluating its diagnostic or therapeutic potential. Commercial CCL16 antibodies are typically validated for applications like ELISA, Western blotting, and immunohistochemistry, aiding both basic research and drug development efforts.
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