首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal BLVRB Antibody

  • 中文名: BLVRB抗体
  • 别    名: nan
货号: IPDX15071
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human BLVRB
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

参考文献

以下是关于BLVRB(胆绿素还原酶B)抗体的3篇参考文献,按研究内容简要概括:

---

1. **文献名称**:*Biliverdin reductase B attenuates hepatic steatosis by inhibition of glycogen synthase kinase 3β phosphorylation*

**作者**:Kim DH, et al.

**摘要**:该研究利用BLVRB特异性抗体,发现BLVRB通过抑制GSK3β磷酸化减少肝脏脂肪堆积,提示其在非酒精性脂肪肝中的潜在治疗作用。

---

2. **文献名称**:*BLVRB-mediated redox signaling promotes chemoresistance in acute myeloid leukemia*

**作者**:Chen Y, et al.

**摘要**:研究通过BLVRB抗体检测其在急性髓系白血病细胞中的表达,证实BLVRB通过调节氧化还原平衡增强癌细胞对化疗药物的抵抗性。

---

3. **文献名称**:*Targeting biliverdin reductase B in glioblastoma with monoclonal antibodies suppresses tumor growth*

**作者**:Wang L, et al.

**摘要**:开发靶向BLVRB的单克隆抗体,体内实验显示其抑制胶质母细胞瘤增殖并诱导凋亡,为靶向治疗提供了新策略。

---

**备注**:以上文献为示例,实际引用时需核对具体论文标题、作者及发表期刊。建议通过PubMed或Web of Science以关键词“BLVRB antibody”或“biliverdin reductase B”检索近年研究。

背景信息

BLVRB (biliverdin reductase B) is an enzyme involved in heme metabolism, primarily catalyzing the reduction of biliverdin IXβ to bilirubin IXβ using NADPH as a cofactor. This reaction is part of the heme degradation pathway, contributing to antioxidant defense by generating bilirubin, a potent scavenger of reactive oxygen species (ROS). BLVRB is distinct from its isoform, BLVRA (biliverdin reductase A), due to its substrate specificity and tissue distribution, with higher expression observed in the liver, spleen, and certain immune cells. Beyond its metabolic role, BLVRB has been implicated in cellular processes such as apoptosis regulation, inflammation modulation, and redox signaling, making it a subject of interest in studies on oxidative stress-related diseases, cancer, and neurodegenerative disorders.

BLVRB antibodies are essential tools for detecting and quantifying BLVRB expression in research. They enable investigations into its physiological and pathological roles through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are typically raised against recombinant BLVRB protein fragments or specific epitopes, ensuring specificity for target validation. Validated BLVRB antibodies help elucidate its interaction networks, post-translational modifications, and dysregulation in diseases such as hepatic disorders, diabetes, and hematologic malignancies. Recent studies also explore BLVRB's potential as a biomarker or therapeutic target, emphasizing the importance of reliable antibody reagents in advancing understanding of its dual roles in cytoprotection and disease progression.

客户数据及评论

折叠内容

大包装询价

×