Mouse Monoclonal SSB Antibody

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     Western blot analysis using SSB mouse mAb against  K-562 lysate    

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     Lane 1: K-562 lysate ;  Lane 2: SSB immunoprecipitated from K-562 lysate by P15070 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15070 can immunoprecipitate SSB;    

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     IHC-P analysis of colon tissue by SSB antibody (P15070) IHC-P was performed using sections of the formalin-fixed paraffin-embedded colon tissue;Result: Glandular cells and lamina propria cell are positively stained at the nuclei.    

SSB antibodies, also called anti-La antibodies, are autoantibodies targeting the SSB (Sjögren’s syndrome antigen B) protein, a 48-kDa phosphoprotein associated with RNA molecules. These antibodies are primarily linked to autoimmune disorders, particularly Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). SSB antibodies often coexist with SSA (Ro) antibodies, forming a complex involved in RNA processing, including the maturation of RNA polymerase III transcripts. Their presence is detected via immunoassays like ELISA or immunoblotting and serves as a diagnostic biomarker.

In Sjögren’s syndrome, SSB antibodies are associated with more severe glandular dysfunction and extraglandular manifestations, such as vasculitis or renal involvement. While SSB antibodies are less common than SSA antibodies, their specificity for SS is higher, especially when both antibodies are present. In SLE, they correlate with photosensitivity, neonatal lupus, and congenital heart block in infants born to mothers with these antibodies. The pathogenic role of SSB antibodies remains unclear, though they may contribute to autoimmune responses by disrupting RNA-protein interactions or promoting apoptosis.

Research suggests genetic factors, particularly HLA-DR3 haplotypes, influence SSB antibody production. Despite their diagnostic utility, SSB antibodies are not exclusive to autoimmune diseases and can occur in other conditions, necessitating clinical correlation. Their detection aids in subclassifying autoimmune disorders and guiding prognostic evaluations.