Mouse Monoclonal PKD2 Antibody

The PKD2 antibody is a crucial tool in studying polycystin-2. a protein encoded by the *PKD2* gene, which is associated with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2. also known as TRPP2. functions as a calcium-permeable non-selective cation channel, often interacting with polycystin-1 (encoded by *PKD1*) to regulate cellular calcium signaling, mechanosensation, and epithelial cell polarity. Mutations in *PKD2* account for approximately 15% of ADPKD cases, leading to cyst formation in kidneys and other organs. Researchers use PKD2 antibodies to detect and quantify polycystin-2 expression in tissues or cell lines, aiding in understanding its localization, interaction partners, and role in disease pathogenesis. These antibodies are commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using PKD2 antibodies have revealed reduced polycystin-2 levels in cystic tissues, suggesting disrupted calcium homeostasis as a key factor in cystogenesis. Additionally, they help investigate post-translational modifications and signaling pathways involving polycystin-2. contributing to therapeutic development targeting ADPKD. Commercial PKD2 antibodies are typically raised against specific epitopes, with validation in knockout models ensuring specificity. Challenges remain in standardizing detection methods due to the protein's large size and complex membrane topology. Overall, PKD2 antibodies remain indispensable for both basic research and clinical diagnostics in polycystic kidney diseases.