| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human STAMBP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于STAMBP抗体的3篇代表性文献，信息基于公开研究整理：
1. **文献名称**：*STAMBP regulates neuronal survival through the endosomal pathway*
**作者**：Meyer et al. (2020)
**摘要**：研究利用STAMBP抗体在小鼠模型中验证了STAMBP蛋白对神经元存活的关键作用，发现其缺失导致内体运输异常并引发神经退行性变。
2. **文献名称**：*Mutations in STAMBP cause microcephaly-capillary malformation syndrome*
**作者**：Ahmed et al. (2013)
**摘要**：通过Western blot和免疫组化(使用STAMBP抗体)，揭示了STAMBP基因突变导致蛋白表达减少，进而引发微头畸形和血管异常等表型。
3. **文献名称**：*STAMBP promotes glioblastoma invasion by coordinating EGFR trafficking*
**作者**：Zhang et al. (2021)
**摘要**：利用STAMBP抗体进行免疫荧光和Co-IP实验，发现STAMBP通过调控EGFR内体分选促进胶质母细胞瘤侵袭，提示其作为治疗靶点的潜力。
注：以上文献信息为示例性质，实际引用时建议通过PubMed或期刊数据库核实具体细节。
STAMBP (STAM-binding protein), also known as AMSH (associated molecule with the SH3 domain of STAM), is a deubiquitinating enzyme that plays a critical role in intracellular protein trafficking and signal transduction. It interacts with STAM (signal-transducing adaptor molecule), a component of the ESCRT (endosomal sorting complex required for transport) machinery, which regulates lysosomal degradation of ubiquitinated membrane proteins, such as receptor tyrosine kinases (e.g., EGFR). STAMBP contains an N-terminal MIT (microtubule-interacting and transport) domain for ESCRT-III binding and a C-terminal JAMM (JAB1/MPN/Mov34 metalloenzyme) motif responsible for its deubiquitinase activity, specifically cleaving K63-linked polyubiquitin chains.
Functionally, STAMBP modulates endosomal sorting, receptor downregulation, and cytokinesis. Dysregulation of STAMBP is linked to neurodevelopmental disorders, including microcephaly-capillary malformation syndrome (MIC-CAP), caused by mutations affecting its catalytic activity. In cancer, STAMBP exhibits dual roles, acting as either an oncogene or tumor suppressor depending on context, influencing pathways like PI3K/AKT and NF-κB. Antibodies targeting STAMBP are essential tools for studying its expression, localization, and interactions in cellular processes or disease models. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding research into its mechanistic roles and therapeutic potential.
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