Mouse Monoclonal ING1 Antibody

The ING1 (Inhibitor of Growth 1) antibody is a research tool used to detect and study the ING1 protein, a tumor suppressor involved in epigenetic regulation, cell cycle control, and apoptosis. Discovered in 1996. ING1 belongs to the ING family of proteins that interact with histone-modifying complexes, such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), to modulate chromatin structure and gene expression. ING1 exists in multiple isoforms, with p33ING1 and p47ING1 being the most studied, differing in subcellular localization and function. Dysregulation of ING1 is linked to cancer progression, neurodegenerative diseases, and aging. Reduced ING1 expression correlates with poor prognosis in various cancers, including breast, colon, and lymphoid malignancies, due to its role in promoting apoptosis and maintaining genomic stability via p53-dependent and independent pathways. ING1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, subcellular distribution, and interactions in experimental models. They aid in elucidating ING1's involvement in DNA repair, senescence, and chromatin remodeling. However, some studies report conflicting roles (tumor-suppressive vs. oncogenic), highlighting context-dependent regulatory mechanisms. Commercially available ING1 antibodies vary in specificity, targeting different isoforms or post-translational modifications, requiring careful validation for experimental accuracy.