Mouse Monoclonal DNAJB6 Antibody

The DNAJB6 antibody is a tool used to detect and study DNAJB6. a member of the HSP40/DNAJ protein family, which functions as a co-chaperone with HSP70. DNAJB6 plays a critical role in protein quality control by assisting in folding, preventing aggregation, and facilitating degradation of misfolded proteins. It is particularly notable for its ability to suppress the aggregation of amyloidogenic proteins linked to neurodegenerative diseases, such as α-synuclein and polyglutamine-expanded huntingtin. Two isoforms exist (DNAJB6a and DNAJB6b), differing by a nuclear localization signal in DNAJB6a, which allows cytoplasmic and nuclear localization, while DNAJB6b is primarily cytoplasmic. Mutations in DNAJB6 are associated with limb-girdle muscular dystrophy (LGMD) due to impaired chaperone activity. Researchers use DNAJB6 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression, subcellular distribution, and interactions in disease models. These studies aim to elucidate its protective mechanisms in proteinopathies and its potential as a therapeutic target. The antibody’s specificity for distinguishing isoforms or post-translational modifications is crucial for understanding context-dependent roles in stress responses and cellular homeostasis.