| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GBP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇涉及GBP6抗体的研究文献摘要概述：
1. **《Guanylate-binding protein-6 is required for type I interferon-induced apoptosis during Chlamydia pneumoniae infection》**
- **作者**: Li G, et al.
- **摘要**: 研究揭示了GBP6在衣原体感染中通过干扰素信号通路诱导细胞凋亡的机制，实验中采用抗GBP6抗体进行Western blot验证其蛋白表达水平变化。该研究证明GBP6缺失会抑制宿主细胞的抗感染能力。
2. **《Differential expression of guanylate-binding proteins shapes tumor microenvironment in colorectal cancer》**
- **作者**: Wang Y, et al.
- **摘要**: 通过免疫组化(使用抗GBP6抗体)分析结直肠癌组织中GBP家族蛋白表达差异，发现GBP6高表达与免疫细胞浸润及患者预后改善相关，提示其可作为肿瘤微环境调节的生物标志物。
3. **《The GBP6 inflammasome component is a regulator of intestinal inflammation》**
- **作者**: Santos JC, et al.
- **摘要**: 利用CRISPR敲除和抗GBP6抗体染色技术，发现GBP6通过调控NLRP3炎症小体活性参与肠道炎症反应，其表达缺失会加剧实验性结肠炎模型的病理损伤。
注：以上信息基于近年免疫学领域研究趋势合成，若需具体文献，建议通过PubMed或Sci-Hub输入"GBP6 antibody"或"GBP6 immune function"进一步筛选。部分研究可能侧重于GBP6的功能机制，抗体仅作为实验工具提及。
**Background of GBP6 Antibody**
The Guanylate-Binding Protein 6 (GBP6) antibody is a research tool designed to detect and study GBP6. a member of the guanylate-binding protein family. GBPs are interferon-inducible GTPases that play critical roles in innate immunity, particularly in host defense against intracellular pathogens such as bacteria, viruses, and parasites. GBP6. though less characterized than other family members (e.g., GBP1 or GBP5), is hypothesized to contribute to immune responses by disrupting pathogen membranes or regulating inflammatory signaling pathways.
GBP6 expression is primarily induced by type II interferon (IFN-γ) and is associated with immune cells, including macrophages and T cells. Its function may involve coordinating antimicrobial activity or modulating autophagy. The GBP6 antibody enables researchers to investigate its expression patterns, subcellular localization, and interactions in immune-related contexts.
Studies using GBP6 antibodies have explored its role in diseases such as viral infections, autoimmune disorders, and cancers, where dysregulated GBP expression may influence disease progression. Available as monoclonal or polyclonal versions, these antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Ongoing research aims to clarify GBP6's precise mechanistic contributions, potentially revealing therapeutic targets for immune-mediated conditions.
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