Rabbit Polyclonal MAFB Antibody

The MAFB antibody is a crucial tool in biomedical research, targeting the MAFB transcription factor, a member of the large Maf protein family. MAFB plays pivotal roles in cell differentiation, development, and tissue homeostasis, particularly in hematopoiesis, osteoclastogenesis, and pancreatic β-cell regulation. Structurally, MAFB contains a basic leucine zipper (bZIP) domain enabling DNA binding and dimerization. In research, MAFB antibodies (polyclonal or monoclonal) are widely used to detect MAFB expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies help identify MAFB-expressing cells, such as monocytes, macrophages, and specific renal podocytes. Clinically, MAFB is implicated in diseases like multiple myeloma, where its overexpression is a diagnostic marker, and in acute myeloid leukemia (AML) with genetic rearrangements. MAFB antibodies also aid in studying immune disorders, diabetes, and developmental pathways. Their specificity and validation (e.g., knockout controls) are critical to ensure accurate results. As MAFB's regulatory roles in gene networks gain attention, its antibodies remain essential for unraveling molecular mechanisms in cancer, immunology, and organogenesis.