| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Gx; EN-7; IMD73A; IMD73B; IMD73C; HSPC022; p21-Rac2 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RAC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAC2抗体的3篇代表性文献(基于模拟信息整理，非真实文献)：
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1. **标题**：*Structural insights into RAC2 activation and GTPase signaling in immune cells*
**作者**：Chen, L., Williams, D.A., et al.
**摘要**：本研究利用冷冻电镜解析了RAC2-GTP复合物的三维结构，揭示了其与中性粒细胞NADPH氧化酶互作的分子机制。文中使用特异性RAC2单克隆抗体进行免疫共沉淀实验，验证了RAC2在活性状态下与下游效应蛋白的结合模式，为免疫缺陷疾病的治疗靶点提供了结构基础。
2. **标题**：*RAC2 deficiency alters neutrophil chemotaxis and phagosomal function*
**作者**：Dinauer, M.C., Ambruso, D.R., et al.
**摘要**：通过Western blot和流式细胞术分析RAC2缺陷患者的中性粒细胞，发现RAC2抗体检测显示蛋白表达显著降低。研究证实RAC2缺失导致细胞迁移障碍及活性氧(ROS)生成缺陷，揭示了其在慢性肉芽肿病(CGD)中的关键作用，并探讨了抗体在诊断此类免疫缺陷中的应用价值。
3. **标题**：*Targeting RAC2 signaling in T-cell acute lymphoblastic leukemia*
**作者**：Garcia-Rodriguez, S., Mulloy, J.C., et al.
**摘要**：该研究开发了一种靶向RAC2 C端表位的兔多克隆抗体，用于抑制RAC2介导的PI3K/AKT通路活化。实验显示，抗体处理可显著降低白血病细胞的增殖和侵袭能力，提示RAC2抗体在癌症靶向治疗中的潜在应用。
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**说明**：以上文献为模拟示例，实际研究中建议通过PubMed或Google Scholar以关键词“RAC2 antibody”、“RAC2 immune function”等检索最新文献，重点关注《Blood》《Journal of Immunology》《Nature Cell Biology》等期刊。
**Background of RAC2 Antibody**
RAC2 (Ras-related C3 botulinum toxin substrate 2) is a small GTPase belonging to the Rho family, which plays critical roles in regulating cytoskeletal reorganization, cell migration, and intracellular signaling. Primarily expressed in hematopoietic cells, RAC2 is essential for immune functions, including neutrophil activation, phagocytosis, and reactive oxygen species (ROS) production via NADPH oxidase. Dysregulation of RAC2 is linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), and inflammatory diseases.
RAC2-specific antibodies are vital tools for studying its expression, localization, and activity in immune cells. These antibodies enable detection of RAC2 in techniques like Western blotting, immunofluorescence, and flow cytometry, aiding research into its role in immune responses and disease mechanisms. For instance, gain-of-function RAC2 mutations are associated with altered neutrophil function and immunodeficiency, while loss-of-function mutations may contribute to autoimmune conditions.
Additionally, RAC2 antibodies are used to explore its interaction with downstream effectors (e.g., PAK1. WAVE complex) and upstream regulators (e.g., GEFs, GAPs). Such studies provide insights into pathways driving inflammation, cancer metastasis, or immune evasion. As RAC2 emerges as a potential therapeutic target, its antibodies also support drug development by validating target engagement or monitoring therapeutic efficacy in preclinical models. Overall, RAC2 antibodies are indispensable for unraveling its multifaceted roles in health and disease.
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