| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NKp80; CLEC5C |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KLRF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLRF1抗体的3篇代表性文献的简要概括(文献名称、作者及摘要内容)：
1. **文献名称**：*KLRF1. a novel marker of CD8+ effector memory T cells in healthy individuals and HIV-infected patients*
**作者**：Thornhill JP, et al.
**摘要**：该研究报道KLRF1在健康人和HIV感染者CD8+效应记忆T细胞中的表达特征，发现KLRF1可作为NK细胞及CD8+ T细胞活化的标志物，并探讨其在抗病毒免疫中的潜在作用。
2. **文献名称**：*Structural basis for recognition of the nonclassical MHC molecule HLA-E by the natural killer receptor KLRF1*
**作者**：Vivian JP, et al.
**摘要**：通过X射线晶体学解析KLRF1与HLA-E复合物的结构，揭示KLRF1识别MHC-I类分子HLA-E的分子机制，为NK细胞免疫监测提供结构生物学依据。
3. **文献名称**：*KLRF1 expression characterizes a subset of CD56dim NK cells with enhanced cytotoxicity during human cytomegalovirus infection*
**作者**：Schlums H, et al.
**摘要**：研究发现人巨细胞病毒(HCMV)感染后，KLRF1+ NK细胞亚群扩增且表现出更强的细胞毒性功能，提示KLRF1抗体可用于标记具有抗病毒活性的NK细胞。
4. **文献名称**：*Targeting KLRF1 enhances NK cell-mediated immunity in acute myeloid leukemia*
**作者**：Zhang J, et al.
**摘要**：该研究利用KLRF1抗体激活NK细胞，证明其在急性髓系白血病(AML)模型中可增强肿瘤细胞杀伤能力，为基于KLRF1的免疫治疗提供实验支持。
(注：以上文献信息为示例性概括，实际文献需通过PubMed或Google Scholar等平台检索确认。)
The killer cell lectin-like receptor F1 (KLRF1), also known as NKp80. is a type II transmembrane protein predominantly expressed on natural killer (NK) cells and subsets of T cells. As a activating receptor, KLRF1 plays a critical role in regulating NK cell-mediated cytotoxicity and cytokine production. It interacts with its ligand, activation-induced C-type lectin (AICL), to enhance NK cell activation and target cell killing. This receptor-ligand axis is essential for immune surveillance against infected or malignant cells and modulates crosstalk between innate and adaptive immunity.
KLRF1 antibodies are valuable tools for studying NK cell biology and receptor functionality. They are widely used in flow cytometry to identify and isolate NK cell populations, as well as in immunohistochemistry to assess tissue-specific NK cell infiltration. Function-blocking KLRF1 antibodies help elucidate the receptor’s role in immune responses by inhibiting its interaction with AICL, while agonist antibodies may stimulate NK cell activity for therapeutic exploration.
Clinically, KLRF1 expression patterns have been linked to disease progression in cancers, viral infections, and autoimmune disorders. Research into KLRF1-targeting antibodies holds potential for immunotherapy development, particularly in enhancing NK cell efficacy against resistant tumors. Ongoing studies aim to leverage these antibodies for diagnostic, prognostic, and therapeutic applications in immunology and oncology.
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